摘要
目的通过2型糖尿病患者血糖值与胰岛素、C-肽和糖化血红蛋白含量关系,了解2型糖尿病患者糖代谢和胰岛B细胞的关系。方法对51例初诊2型糖尿病患者及48名正常人餐前血糖、胰岛素、C-肽和糖化血红蛋白含量分别采用酶法、放免法、免疫散射比浊法进行测定,采用SPSS15.0软件进行分析。结果实验组空腹血糖、胰岛素、C-肽以及糖化血红蛋白分别为(9.93±2.91)mmol/L,(24.27±11.44)μU/L,(3.93±1.39)μg/L,(6.93±1.63)%,均高于对照组的(5.05±0.57)mmol/L,(15.47±6.26)μU/L,(2.35±0.85)μU/L,(4.74±0.50)%,差异均有统计学意义(P<0.01);2型糖尿病患者不同年龄组间4项指标差异均无统计学意义;空腹血糖与糖化血红蛋白呈高度正相关,且实验组血糖含量的变异有64.4%可由胰岛素、C-肽和糖化血红蛋白的变化来解释(R2=0.644)。结论2型糖尿病患者的血糖、胰岛素、C-肽和糖化血红蛋白均高于正常人。胰岛素、C-肽和糖化血红蛋白的改变可引起血糖升高。
Objective To explore the relationship between glycometabolism and pancreatic B cell in type Ⅱ diabetes. Methods Fifty-one patients with newly diagnosed type Ⅱ diabetes and forty-eight normal persons were selected. The fasting blood glucose,insulin, C-peptide and HbA1 c were determined with radioimmunoassay, enzyme-linked immunosorbent assay and immune nephelometry. Results For newly diagnosed type Ⅱ diabetes patients, the values of fasting C-peptide,insulin, HbA1c and fasting blood glucose were higher than that of the normal（P 〈0.01 ） ,and HbA1c and fasting blood glucose were positively correlated. Glucose content changed wih diversification of C-peptide, insulin and HbA1 c. Conclusion The value of fasting C-peptide,blood glucose,insulin and HbA1c of type Ⅱ diabetes patients are higher than that of the normal. Diversification of C-peptide, insulin, HbA1 c can cause blood glucose elevation.
出处
《中国公共卫生》
CAS
CSCD
北大核心
2009年第4期404-405,共2页
Chinese Journal of Public Health
作者简介
杨光（1969-），女，黑龙江人，副主任检验师，硕士在读，研究方向：糖尿病与微量元素的关系。
通讯作者：王德才
