摘要
目的:观察人参皂甙Rg3胶囊联合肝动脉化疗栓塞治疗中晚期肝癌的临床疗效。方法:将61例患者随机分为两组:治疗组30例给予人参皂甙Rg3胶囊联合肝动脉介入治疗,对照组31例给予单纯肝动脉介入治疗。结果:治疗组近期有效率及疾病控制率分别为33.3%(10/30)、80.0%(24/30),对照组为29.0%(9/31)、58.1%(18/31);治疗组中位生存期为10个月,对照组为9个月,差异均无统计学意义(P>0.05);治疗组生活质量改善率高于对照组(P<0.05)。结论:人参皂甙Rg3胶囊联合肝动脉化疗栓塞术治疗中晚期肝癌可显著改善患者的生活质量,值得临床进一步研究。
Objective ： To evaluate the clinical eficacy of ginsenoside Rg3 capsules combined with transcatheter arterial chemoembolization（TACE） in the treatment of advanced hepatocellular carcinoma. Methods：Sixty-one patients with advanced hepatoeellular carinoma were randomized into two groups：thirty patients were treated with ginsenosidc Rg3 plus TACE as the treatment group, thirty-one patients only received TACE as the control group. The clinical efficacy was evaluated 1 month later after the therapy. Results：For the treatment group and the control group,the response rate of two groups was 33.3% and 29.0% （P 〉 0. 05 ）. The disease control rate was 80.0% in treatment group and 58. 1% in the control group（P 〈0. 05）. The median survival time was 10 months and 9 months（P 〉 0. 05 ）. KPS scale was improved in the treatment group （P 〈 0. 05 ）. Conclusion：Preliminary results show improvements in response rate and quality of life in ginsenosides Rg3 combined with interventional therapy. It is worthy to confirm the results in further clinical trials.
出处
《临床肿瘤学杂志》
CAS
2009年第2期150-153,共4页
Chinese Clinical Oncology
关键词
人参皂甙RG3
肝癌
化疗栓塞术
Ginsenoside Rg3
Hepatollcellular carcinoma
Transcatheter arterial chemoembolization
