摘要
以流感病毒Ａ／ＦＭ１／１／４７（Ｈ１Ｎ１）鼠适应株，鼻腔内接种感染小鼠为模型，探讨了病毒感染过程中，自由基的产生以及在致病过程中的作用．结果表明，感染病毒的小鼠肺组织中氧自由基水平和黄嘌呤氧化酶活性显著升高，并与肺组织损伤和死亡率之间呈正相关．提示，氧自由基参与了病毒感染小鼠的致病过程，是造成组织损伤的重要因素．
To prove up production and effect of free radicals on virusinduced pathogenesis, the influenza A/FM1/1/47 (H1N1) was adapted to mice by nostril inoculation. The results demonstrated that the oxygen free radical levels and xanthine oxidase activity in the lung tissues from the mice after infection by virus raised remarkably. These were positively correlated with lung tissues injury and mice mortality. The results demostrated that oxygen free radicals may involve in influenzainduced pathogenesis in mice, and may be an important factor causing tissue injury.
出处
《生物化学与生物物理进展》
SCIE
CAS
CSCD
北大核心
1998年第2期180-183,共4页
Progress In Biochemistry and Biophysics
关键词
流感病毒
氧自由基
感染
influenza, oxygen free radicals, mice
