摘要
目的探讨孕妇IgG血型抗体与ABO新生儿溶血病发生率之间的关系。方法对2700例O型Rh阳性夫非O型孕妇行IgG抗-A（B）效价测定，对其中280例有新生儿溶血病（HDN）危险的孕妇所生新生儿行HDN血型血清学检查即ABO、Coomb实验、游离和释放实验）以了解孕妇IgG血型抗体效价高低与ABO—HDN发病率之间的关系。结果2700例O型孕妇中，IgG抗-A（B）效价〈64、64、128、256和≥512各组分别占62．4％、16．8％、12．6％、5．8％和2．4％。280例母婴血型不和且有ABO—HDN危险的孕妇所生新生儿中共有67例HDN阳性，占23．9％；孕妇IsG抗-A（B）效价为64、128、256、和≥512各组HDN阳性率分别为10．2％、27．8％、45．7％和50．0％（P〈0．01）。结论孕妇血清中IgG抗-A（B）效价高低与ABO—HBN的发生率成正相关。产前进行血清IgG效价抗体检测非常必要。
Objective To study the relationship between blood group antibody IgC titer of pregnant women and ABO hemolytic disease of newborn （HDN）. Methods Blood group antibody IgG titers of 2700 pregnant women who is O and Rh positive with a non-O husband were detected. After born,blood groups,Coomb＇s test,free antibody and antibody release test were done for those 280 babies who were in high risk of HDN, so that we could understand the relationship between the antibody IgG level of pregnant women and ABO-HDN. Results The percent of anti-A （B） IgG titer 〈 64,64,128,256 and ≥512 in the 2700 O type pregnant women was 62.4%, 16. 8%, 12.6% ,5.8% and 2.4% ,respectively. There were 67 babies suffered from HDN in those 280 babies who had high risk,which accoun12, the percentted for 23.9%. With the anti-A （B） IgG titer was 64,128,256 and ≥ 5 of HND positive was 10. 2% ,27. 8% ,45.7% and 50.0% ,respectively（ P 〈 0. 01 ）. Conclusion There is a positive relationship between blood group antibody IgG titer of pregnant women and ABO-HDN. It is necessary for the pregnant women to detect the level of anti-A（B） IgG.
出处
《中国基层医药》
CAS
2008年第12期1984-1985,共2页
Chinese Journal of Primary Medicine and Pharmacy
