摘要
目的:研究孕妇产前免疫球蛋白(IgG)抗-A(B)不同的效价对新生儿红细胞致敏及发生高胆红素血症的情况。方法:对妻O型、夫A、B及AB型,妊娠37周后的待产孕妇进行IgG抗-A(B)效价测定,对出生后血型为A或B型的新生儿脐血进行血清学检验。结果:①在271例母子血型不合的新生儿中,当孕妇IgG抗-A(B)效价<1∶32时,新生儿血清学检验结果均为阴性;当孕妇IgG抗-A(B)效价≥1∶32时,从低至高新生儿红细胞被IgG抗-A(B)致敏的阳性率及血液中游离抗体的阳性率均显著增高(P<0.05);②224例红细胞被IgG抗-A(B)致敏的新生儿与对照组的新生儿高胆红素血症的发生率有极显著性差别(P<0.01);③孕妇IgG抗-A(B)效价≤1∶64与≥1∶128比较,新生儿高胆红素血症的发生率有极显著性差别(P<0.01)。结论:孕妇IgG抗-A(B)效价≥1∶32时,可引起新生儿高胆红素血症;孕妇IgG抗-A(B)效价与新生儿发生高胆红素血症呈显著正相关。
Objective： To research into the situation about the different immunoglobulin Ab -A （B） titer before the pregnant woman delivery how to sensitive the neonate＇s erythrocyte and to develop hyperbilirubinemia. Methods： Ab - A （B） titer of the pregnant for 37 weeks whose blood type were O and their husbands＇were A, B or AB and the serology with umbihcal blood of those whose blood type wais A or B after birth were determined. Results： ①In the 271 neonates without matched blood type with their mothers, when the pregnant woman Ab - A （B） titer 〈 1： 32, the result of serology was negative; whereas, when Ab - A （B） titer≥ 1 ： 32, from low to high, the positive incidence of erythrocyte which sensitized by the Ab - A （B） and the free antibody in blood heightened remarkably （P 〈 0. 05）. ②In the 224 cases which erythrocyte was sensitized by the Ab - A （ B）, it put up a remarkable difference in developing hyperbilirubinemia comparing to those in control group （P 〈 0. 01 ）. ③Comparing the titer≤ 1：64 to the titer≥ 1： 128, it had a remarkable difference in developing hyperbilirubinemla too （P 〈 0. 01 ） . Conclusion： When the Ab -A （B） titer≥ 1：32, it may develop hyperbilirubinemia; the higher of the titer, the higher of the morbidity.
出处
《中国妇幼保健》
CAS
北大核心
2007年第17期2377-2379,共3页
Maternal and Child Health Care of China
基金
广东省中山市科技局科研课题基金项目(2006C044)
关键词
孕妇
免疫球蛋白
抗体效价
致敏
高胆红素血症
Pregnant woman
Immunoglobulin
Antibody titer
Sensitization
Hyperbilirubinemia
作者简介
通讯作者
