宫颈电圈环切术对妊娠结局影响的Meta分析被引量：30

A Meta Analysis of Pregnancy Outcome after Loop Electrosurgical Excision Procedure

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摘要目的:探讨宫颈电圈环切术(LEEP)对妊娠结局的影响。方法:通过计算机检索1990～2007年国内外公开发表的有关宫颈LEEP术对妊娠结局影响的相关文献,采用荟萃(Meta)分析的方法,对入选的8篇外文文献中病例对照研究进行定量综合分析。应用RevMan 4.2统计软件计算合并优势比(OR)及95%可信区间(CI)。结果:①LEEP术组的早产发生危险度是对照组的1.56倍(合并OR=1.56,95%CI为1.26～1.92);②LEEP术组孕周<37周的胎膜早破(pPROM)发生危险度是对照组的3.17倍(合并OR=3.17,95%CI为2.12～4.74);③LEEP术组的低体重儿(LBW)发生危险度是对照组的1.60倍(合并OR=1.60,95%CI为1.16～2.22);④无证据表明LEEP术将会影响剖宫产率(合并OR=0.95,95%CI为0.75～1.15)。结论:LEEP术可增加术后妊娠早产、pPROM、LBW发生率,对剖宫产率没有影响。 Objective：To investigate the influence of loop electrosurgical excision procedure （LEEP） on subsequent pregnancy outcomes. Methods： 8 published case-control references about pregnancy outcomes after loop electrceurgical excision procedure from 1990 to 2007 were collected. Meta-analysis method was applied with RevMan4.2 software to calculate the odds ratio. Results：The incidence of preterm birth in LEEP group was 1.56 times of that in control （overall OR = 1.56, 95% CI： 1.26 - 1.92） ; the incidence of premature PROM was 3.17 times of that in control （overall OR = 3.17, 95% CI. 3.12 -4.74）; and the incidence of low birth weight infants was 1.60 times of that in control （overall OR = 1.60, 95% CI; 1.16 - 2.22）. There was no difference in cesarean delivery rate （overall OR = 0.95, 95% CI; 0.75 - 1.15） .Conclusions.Women who had LEEP were more likely to have preterm birth, premature PROM, and low birth weight infants, but there was no difference in cesarean delivery rate.

作者王娟胡建铭

机构地区苏州大学附属第一医院

出处《实用妇产科杂志》 CAS CSCD 北大核心 2009年第1期41-43,共3页 Journal of Practical Obstetrics and Gynecology

关键词宫颈电圈环切术早产荟萃分析 Loop electrosurgical excision procedure Preterm birth Meta analysis

分类号 R713.4 [医药卫生—妇产科学]

作者简介通讯作者：胡建铭，Email：hu_jm2001@yahoo．com.cn

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参考文献16

1Mathevet P, Dargent D, Roy M, et al. A randomized prospective study comparing three techniques of conization: cold knife, laser, and LEEP [J]. Gynecol Oncol,1994,54(2): 175- 179.
2Ellenberg SS. Meta-analysis: the quantitive approach to research review [J] .Seminats Oncol, 1988,15(5) : 427.
3Blomfield PI, Buxton J, Dunn J, et al. Pregnancy outcome after large loop excision of the cervical transformation zone [J]. Am J Obstet Gynecol, 1993,169(3) : 620 - 625.
4Cruickshank ME, Flannelly G, Campbell DM, et al. Fertility and pregnancy outcome following large loop excision of the cervical transformation zone [J].Obstet Gynecol Sur, 1996,51(3): 168- 169.
5White K,Lindsay M,Raynor BD,et al.Pregnancy outcome after loop electrosurgical excision procedure of the cervix [J]. Am J Obstet Gynecol, 2001,184(1) : S190.
6Tufano S, Rowin C, Deroche M, et al.Tne effect of loop electroexcision procedure and cone biopsy on pregnancy outcome [ J]. Am J Obstet Gynecol, 2002,187(6) : S84.
7Linda TE,Pepra RK.The outcome of pregnancy after large loop exeisionof the transformalion zone of the cervix [J]. J Obstet Gynecol, 2004,24( 1 ) : 25 - 27.
8Sadler L, Saftlas A, Wang WQ, et al. Treatment for cervical lntraepitheiial neoplasia and risk of preterm delivery [J] .JAMA,2004,219( 17): 2100- 2106.
9Ganesh A, Ingvild K, Sidsel M, et al. Pregnancy outccrae after loop electrosurgical excision procedure for the management of cervical intraepithelial neoplasia [ J ]. Arch Gynecol Obstet, 2005,272 ( 2 ) : 109 - 112.
10Samson SLA,Bentley JR,Fahey TJ, et al.The effect of loop electrosurgical excision procedure on future pregnancy outcome [J]. Obstet Gynecol, 2005,105(2) : 325 - 332.