摘要
目的探讨注射用磷酸肌酸钠治疗难治性心力衰竭的临床疗效。方法将26例难治性心力衰竭患者随机分为对照组（13例）和治疗组（13例）。对照组给予吸氧、休息、强心、利尿、扩血管、抗感染、纠正心律失常和电解质紊乱，控制液体入量。治疗组在对照组治疗的基础上加生理盐水100—250m1加注射用磷酸肌酸钠1—2g，静脉滴注，1次／d。两组均两周为一疗程。结果治疗组临床疗效优于对照组（总有效率92．3％对76．9％，P〈0．05）；治疗组治疗后LVEF明显改善（P〈0．01），且优于对照组（P〈0．05）；治疗组治疗后V1导联P波终末电势较对照组明显改善（P〈0．01）。结论注射用磷酸肌酸钠能提高临床疗效，改善左心室射血分数（LVEF）和V1导联P波终末电势，是治疗难治性心力衰竭的有效药物。
Objective To investigate the clinical efficacy of creatine phosphate sodium in patients with refractory heart failure. Methods The 26 patients with refractory heart failure were randomly divided into treatment group （ n = 13 ） and control group （ n = 13 ）. Standard therapeutic scheme is used in control group, standard therapeutic scheme creatine phosphate sodium was used in treatment group. Treatment group was treated with creatine phosphate sodiun, 1 -2g intravenous drip once a day. Two weeks as a treatment course. Results In treatment group, total clinical effective rate is 92. 3% ; control group is 76. 9%. The clinical efficacy in treatment group is higher than control group （P 〈 0. 05 ）. Left ventricular rejection fraction （LVEF） increased in treatment group with significant difference comparing with control group（ P 〈 0. 05 ）. In treatment group, the terminal force of P wave in lead vl was improved ,it was a statistical significant compared to control group（P 〈 0. 01 ）. Conclusion Creatine phosphate sodium is increased the clinical efficacy, improved the LVEF and the terminal force of P wave in lead vl is effective drug in treatment of refractory heart failure.
出处
《中国医学创新》
CAS
2009年第1期16-17,共2页
Medical Innovation of China
关键词
注射用磷酸肌酸钠
难治性心力衰竭
临床观察
Creatine phosphate sodium
Refractory heart failure
Clinical observation
作者简介
通讯作者：张全贵
