摘要
【目的】研究慢性盆腔炎性不孕患者子宫内膜整合素αvβ3的表达,并分析其体内甾体激素与整合素αvβ3表达的相关性。【方法】选取25例慢性盆腔炎性不孕症患者,同时选择15例具有正常生育能力的育龄妇女,分别设为实验组和对照组,采用流式细胞荧光标记测量技术对子宫内膜中整合素αvβ3的表达进行定量检测。在同期内取血清检测实验组及对照组体内雌孕激素水平,分析甾体激素与子宫内膜整合素αvβ3表达在植入窗口期(种植期)的相关性。【结果】(1)两组黄体中期血清雌二醇(E2)水平及雌二醇/孕酮(E2/P)比值比较均无显著性差异(P>0.05),而血清P水平比较有显著性差异(P<0.05)。(2)两组黄体中期(分泌中期)子宫内膜整合素αvβ3表达比较差异有显著性意义(P<0.05)。(3)雌激素与子宫内膜整合素αvβ3无相关性,而孕激素与整合素αvβ3显示正相关性,孕激素的表达水平越高,整合素αvβ3表达水平相应也越高。【结论】整合素αvβ3在正常育龄妇女子宫内膜种植窗期的表达高于慢性盆腔炎性不孕患者;整合素的表达水平与卵巢分泌的甾体激素孕激素的表达呈一致性,孕激素影响着整合素αvβ3表达的水平。
Objective To observe the expression of endometrial integrin-αvβ3 in patients with infertility induced by chronic pelvic inflammatory disease （ CPID）, and to analyze the correlation of steroid hormone level with integrin-αvβ3 expression. Methods Twenty-five infertile patients induced by CPID were enrolled into the experimental group, and 15 women with normal reproductive capability at reproductive age served as the control. The expression of endometrial integrin-αvβ3 was measured by flow cytometry. Meanwhile, serum estrogen （ E2 ） and progesterone （P） levels were tested , and the correlation of serum steroid hormone level with endometrial integrin-αvβ3 expression was analyzed during the same implantation window stage. Results In the mid-secretory phase, the difference of E2 and E2/P ratio was insignificant （ P 〉 0. 05 ）, while that of serum P was significant （ P 〈 0.05 ） between the two groups ; the expression of endometrial integrin-αvβ3 in the experimental group differed from that in the control group （P 〈 0. 05 ）. No correlation existed between the estrogen level and the expression of endometrial integrin-αvβ3 , but there existed a positive correlation between the progesterone level and the expression of endometrial integin-αvβ3 . The integrin-αvβ3 expression level increased with the progesterone level. Conclusion In the normal women at reproductive age, the integrin-αvβ3 expression level during implantation window stage is higher than that in the infertile patients induced by CPID; the integrin-αvβ3 expression level is positively correlated with the ovary progesterone level.
出处
《广州中医药大学学报》
CAS
2008年第5期395-397,共3页
Journal of Guangzhou University of Traditional Chinese Medicine
作者简介
廖慧慧（1972-），女，副主任医师
