摘要
【目的】观察穴位埋线联合健脾祛痰中药对肥胖型多囊卵巢综合征(PCOS)患者胰岛素抵抗及脂肪细胞因子的影响。【方法】采用随机数字表法将42例肥胖型PCOS患者随机分为2组,针药组22例予穴位埋线联合加减苍附导痰汤治疗,中药组20例予加减苍附导痰汤治疗。连续治疗3个月为1个疗程。观察2组治疗前后月经情况,检测治疗前后患者的体质量指数(BM I)、空腹血糖(FPG)、空腹胰岛素(FINS)以及胰岛素敏感指数(ISI)、瘦素(Leptin)、肿瘤坏死因子-α(TNF-α)、抵抗素(Resistin)等的变化,记录胰岛素抵抗(IR)者的例数。【结果】月经改善总有效率针药组为81.8%,中药组为65.0%,2组比较差异有显著性意义(P<0.05)。针药组妊娠者3例,中药组妊娠者1例。治疗后2组BM I、FINS、ISI均明显改善,与治疗前比较,差异有显著性意义(P<0.05),其中针药组改善程度更为显著(与中药组比较,P<0.05)。治疗后2组Leptin、TNF-α、Resistin均明显降低(与治疗前比较,P<0.05),其中针药组的Leptin、TNF-α值下降更为显著(与中药组治疗后比较,P<0.05)。【结论】穴位埋线联合健脾祛痰中药治疗肥胖型PCOS患者疗效确切,其效果明显优于单用中药治疗。其作用机制可能与降低BM I及脂肪细胞因子Leptin、TNF-α、Resistin水平,从而改善IR有关。
Objective To observe the effect of acupoint catgut-embedding （ACE） therapy combined with spleen- strengthening and phlegm-removing herbs on insulin resistance （IR） and adipocyte factors in patients with obese-type polycystic ovary syndrome （PCOS）. Methods Forty-two obese-type PCOS patients were randomized into two groups： group A （N=22） received ACE combined with modified Cang Fu Daotan Decoction, and group B （N = 20） received modified Cang Fu Daotan Decoction alone. Three months constituted one treatment course. The change of menstruation was observed, and body mass index （ BMI）, fasting plasma glucose （ FPG）, fasting insulin （FINS） and insulin sensitivity index （ISI）, leptin, tumor necrosis factor α （TNF-α）, and resistin were detected before and after treatment. Meanwhile, the number of patients with IR was also recorded. Results The improvement rate of menstruation was 81.8% in group A and 65.0% in group B （P 〈 0.05）. There were 3 patients being pregnant in group A, and there was one in group B. After treatment, BMI, FINS and ISI were much improved in the two groups （ P 〈 0. 05 ）, and the improvement was obvious in group A （ P 〈 0. 05 ） ; serum levels of leptin, TNF-α and resistin were decreased in the two groups （P 〈 0. 05）, and the decrease of leptin and TNF-α was obvious in group A （ P 〈0. 05 ）. Conclusion Acupoint catgut-embedding therapy combined with spleen-strengthening and phlegm-removing herbs has a better effect than herbs alone for obese-type polycystic ovary syndrome, and its therapeutic mechanism may be related with the decrease of BMI and levels of leptin, TNF-α and restistin.
出处
《广州中医药大学学报》
CAS
2009年第2期134-137,共4页
Journal of Guangzhou University of Traditional Chinese Medicine
基金
广东省科技计划项目(编号:2006B35602006)
关键词
多囊卵巢综合征/中药疗法
多囊卵巢综合征/穴位疗法
埋线
健脾祛痰
POLYCYSTIC OVARY SYNDROME/TCD therapy
POLYCYSTIC OVARY SYNDROME/acupoint therapy
EMBEDDING, THREAD
STRENGTHENING SPLEEN AND REMOVING PHLEGM
作者简介
陶莉莉（1962-），女，教授
