摘要
目的探讨中性粒细胞体积分布宽度(NDW)在诊断急性细菌性感染中的应用价值。方法应用Beck-man Coulter LH750全自动血细胞分析仪,对80例急性细菌性感染患者的血样进行全血细胞分析,综合白细胞总数、中性粒细胞百分比、中性粒细胞体积分布宽度、显微镜形态学检查等各项指标,与50例正常对照组比较。结果急性细菌性感染患者NDW数值较正常对照组明显增高(P<0.01),而且部分急性感染患者白细胞总数<11.0×109/L,中性粒细胞<85.0%,但NDW数值却较正常对照组明显增高(P<0.01),显微镜形态学检查,当NDW>23.0时,可见不同程度中性粒细胞核左移、中性粒细胞体积大小不等、胞浆内出现中毒颗粒等。结论NDW可以作为诊断急性细菌性感染比较敏感特异的一个新指标。
OBJECTIVE To study the value of the application of the neutrophil volume distribution width（NDW） in diagnosing acute bacterial infection generated by Coulter LH750 hematology analyzer. METHODS To do whole blood cell analysis of 80 blood samples of the bacteremic patients. Observed the white blood cell counts（WBC）, the percentages of neutrophils, the value of the NDW and microscopic examination, to compare them with 50 controls. RESULTS A significant increase in the NDW was observed in the bacteremic patients compared with the controls （P〈0.01）. Such increase was observed even in patients with WBC less than 11.0 ×10^9/L, or with percentages of neutrophils less than 85.0%, P〈0.01）. The change in NDW was more sensitive compared to the WBC and the percentages of neutrophils. According to the microscopic examination microscope, when NDW was high than 23.0, we could see the left shift of the circulating granulocytes, with increased variability of cell sizes and shapes, and toxic particles in cytoplasm. CONCLUSIONS So the NDW has potential for use as an additional indicator for diagnosing acute bacterial infection.
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2008年第12期1796-1797,1792,共3页
Chinese Journal of Nosocomiology
