摘要
目的:探讨结直肠癌组织中凋亡抑制基因Survivin和血管内皮生长因子(vascular endothelial growth factor,VEGF)表达与结直肠癌临床病理特征的相关性,及其在结直肠癌发生发展中的作用。方法:应用免疫组织化学方法检测61例结直肠癌及肿瘤切端非癌组织中VEGF及Survivin的表达。结果:Survivin在正常结直肠组织不表达,结直肠癌组织中45例(73.77%)阳性表达,VEGF在非癌结直肠组织不表达,癌组织中42例(68.85%)阳性表达。结直肠癌组织中Survivin及VEGF表达与肿瘤浸润深度、Duke分期及有无淋巴结转移关系密切,P<0.05。结论:Survivin和VEGF参与结直肠癌血管新生的调节,与肿瘤的发生发展及预后有密切关系。
OBJECTIVE： To explore the relationship between the expressions of apoptosis suppression gene Survivin and vascular endothelial growth factor（VEGF） in colorectal carcinoma and their clinicopathologic features,and their role in the development and progression of colorectal carcinoma.METHODES： The expressions of Survivin and VEGF were assayed by immunohistochemical staining（SP） in 61 cases of colorectal carcinoma and their non-carcinomatous ends of cut specimens.RESULTS： The normal colorectal tissues were negative for Survivin,but the positive expression in 45 cases（73.77%） of colorectal carcinoma tissues.The expression of VEGF in 42 cases（68.85%） of colorectal carcinoma was positive,but no expression in normal colorectal tissues.The expressions of Survivin and VEGF in colorectal carcinoma were correlated closely with the extent of tumor invasive,Duke stages and lymph node metastasis,P〈0.05.CONCLUSION： Survivin and VEGF are involved in the regulation of angiogenesis in colorectal carcinoma,and correlated closely with the development,progression and prognosis of colorectal carcinoma.
出处
《中华肿瘤防治杂志》
CAS
2008年第18期1390-1392,共3页
Chinese Journal of Cancer Prevention and Treatment
关键词
结直肠肿瘤
血管生成
血管内皮生长因子
生存素
免疫组织化学
colorectal neoplasms
angiogenesis
vascular endothelial growth factor
Survivin
immunohistochemistry
作者简介
赵姚勃，女，辽宁阜新人，主治医师，主要从事肿瘤病理研究工作。Tel：86-418-3359470
通讯作者简介：姜葱峰，男，山东莱阳人，硕士，主任医师，主要从事肿瘤转移机制和软组织肿瘤诊断病理学研究工作。Tel：86-535-7232231 E-mail：jianghf59@sina．com
