摘要
目的:研究牛磺酸(taurine,Tau)对睡眠剥夺(sleep deprivation,SD)大鼠学习记忆的影响。方法:用小平台水环境(flower pot)法建立SD大鼠模型,SD72h后用Morris水迷宫测定大鼠学习记忆能力。结果:SD72h后逃避潜伏期实验组显著低于对照组,穿环系数实验组显著高于对照组,且以中剂量组的效果最好。结论:牛磺酸对SD所致的大鼠学习记忆障碍有明显的改善作用。
Objective：To study the effect of taurine on learning and memory in rats after sleep deprivation. Methods：Sleep depriration was induced in male Sprague-Dawley rats by using ＂Flower Pot＂ technique. Learning and memory ability in rats were measured by Morris maze after 72 hours sleep deprivation.Results：Compared with control group,the mean escap period of experimental groups decreased significandy after 72 hours sleep deprivation, the crossing annulus coefficie increased markedly,especially in the medium dose group. Conclusion：Taurine can obviously improve the learning and memory dysmnesia in rats induced by Sleep deprivation.
出处
《现代医药卫生》
2008年第19期2866-2868,共3页
Journal of Modern Medicine & Health
基金
河南省卫生厅医学科技攻关计划项目(编号200686)
新乡市科技发展计划项目(编号07s049)
关键词
牛磺酸
睡眠剥夺
学习记忆
Tanrine
Sleep deprivation（SD）
Learning and memory
作者简介
魏林郁（1977-），男，河南南阳人，助教，在读硕士研究生，主要从事神经生物学方面研究。
