摘要
目的探讨多环芳烃(PAHs)在人胃癌发病过程中的作用。方法采用固相萃取(SPE)—高效液相色谱(HPLC)法,测定人正常胃组织和胃癌组织中的5种多环芳烃(PAHs)类化合物。结果胃癌组织中的芘和苯并(a)芘的水平显著高于正常胃组织,两组相比P<0.05;胃癌组织中二甲基萘和菲的水平近似,两者相比,P>0.05。结论人胃组织对PAHs有很强的生物富集能力,PAHs与人胃癌的发生高度相关。
Objective To investigate the effect poly cyclic aromatic hydro carbons （PAH）s in stomach carcinoma genesis. Method PAHs in human gastric tumor and normal stomach were detected with solid phase extraction-high performance liquid chromatography （SPE-HPLC）. Result Pyrene and B （a） P in human gastric tumor were significantly higher than those in normal stomach（ P 〈 0.05 ）, while there were non-significant difference with dimethylnaphthalene and phenanthrene in human gastric tumor and normal stomachs （P 〉 0. 05）. Conclusion Human gastric tissue has an extremely strong ability of bioconcentrating PAHs, which play an important role in the occurrence of human gastric tumor.
出处
《山东医药》
CAS
北大核心
2008年第15期20-21,共2页
Shandong Medical Journal
基金
青岛科技发展指导计划资助项目(2000-178-61)
关键词
胃肿瘤
多环芳烃
gastric carcinoma
polycyclic aromatic hydrocarbons
作者简介
通讯作者
