摘要
[目的]对阿胶铁口服液的饮用安全性进行食品安全性毒理学评价和研究。[方法]根据《食品安全性毒性评价程序》进行小鼠经口急性毒性试验、Ames试验、小鼠骨髓嗜多染红细胞微核试验、小鼠精子畸形试验。[结果]阿胶铁口服液小鼠经口LD50﹥21.5g/kg.bw,属无毒级;鼠伤寒沙门菌/哺乳动物微粒体酶试验、骨髓微核试验及小鼠精子畸变试验表明该样品无致突变作用,对雄性生殖细胞无遗传毒性。[结论]阿胶铁口服液属无毒级物质,对体细胞无致诱变及突变作用。
[Objective ] To evaluate and study the toxicological safety of Donkey-hide Glue Iron Oral Solution. [ Methods] Acute toxicity test, Ames test, bone marrow micronucleus test, sperm malformation test were conducted according to the evaluation procedure of toxicological safety of food. [ Results] Donkey-hide glue iron oral solution with the dose of LD50 〉 21.5g/kg.bw showed to be non-toxic on the mice. Salmanella typhimurium/mammals microsomal enzyme test and micronucleus test of booe marrow cell showed Donkey-hide Glue Iron Oral Solution was safe without mutagenesis. No toxicity was observed in sperm shape abnormality test in mice. [ Conclusion ] Donkey-hide Glue Iron Oral Solution is a non-toxic and non-mutating drug for the body cell.
出处
《现代预防医学》
CAS
北大核心
2008年第18期3602-3604,共3页
Modern Preventive Medicine
关键词
阿胶铁口服液
毒理学安全性
评价
Donkey-hide glue iron oral solution
Toxicology and safety
Assessment
作者简介
许红霞（1970-），女．硕士．研究方向：靶向制剂
通讯作者：高晓黎（1962-）．女．博士，博士生导师．研究方向：靶向给药制剂研究与新疆地产资源新药开发．E-mail：gxli@tefeng.com
