摘要
目的:探讨药物的胶囊剂在应用紫外-可见分光光度法进行溶出度测定时,其空心胶囊对被测主药成分的定量结果的影响。方法:采用紫外-可见分光光度法,氟康唑胶囊(规格:50 mg)的溶出度进行测定。结果:本方法中的空心胶囊的吸光度值,可以导致所测得的溶出度结果平均虚高约20%左右。结论:空心胶囊有可能对溶出度测定中样品的数据造成很大影响,最终影响到对样品溶出度测定结果的评判。
Objective： To discuss the impact of vacant capsules on the quantitive determination of main drug in capsules while assaying dissolution by UV-spectrophotometry. Method, The dissolution of fluconazol capsules was determinated by UV-spectrophotometry. Results： The absorbance of the vacant capsules in this method can lead to the value of the calculated dissolution 20% higher than the value of the average. Conclusion： Vacant capsules may greatly impact the value of dissolution of sample, and finally impact the judgment to dissolution results of samples.
出处
《四川生理科学杂志》
2008年第3期118-119,共2页
Sichuan Journal of Physiological Sciences
作者简介
徐燕，女，主管药师。
通讯作者：张罗红，Email：luohongzh@163．com
