摘要
目的:观察地塞米松治疗双硫仑样反应的临床效果,研究地塞米松对酒精中毒小鼠乙醛脱氢酶活性的影响。方法:应用地塞米松治疗双硫仑样反应患者26例,观察患者临床症状消失的时间和血压恢复情况。48只昆明小鼠随机分为4组:正常组、酒精中毒组、模型组及治疗组。酒精中毒组在正常饲养基础上用50%酒精灌胃,模型组加腹腔注射头孢哌酮钠,治疗组在模型动物腹腔注射地塞米松治疗,1h后处死动物,检测血中乙醛脱氢酶活性和比活性。结果:26例患者全部痊愈出院。治疗组血中乙醛脱氢酶活性和比活性明显高于其它各组(P<0.05)。结论:地塞米松治疗双硫仑样反应能迅速缓解临床症状,其机制可能是通过提高乙醛脱氢酶活性起作用。
Objective：To observe the clinical effect of dexamethasone in treatment of disulfiram-like reaction and to investigate the effect of dexamethasone on the activity of acetaldehyde dehydrogenase in alcoholism mice. Methods： Clinical symptoms and blood pressure of 26 patients with disulfiram-like reaction were observed. Fourty-eight Kun Ming mice were divided into four groups randomly： normal control group, which took normal diet; alcohol control group, which was treated with 50O/oo alcohol on basis of normal diet; model group, which received Cefoperazone Sodium injection intraperitoneally on basis of alcohol control group; treatment group, in which dexamethasone were injected intraperitoneally on basis of the model group. At the end of the experiment, the activity of acetaldehyde dehydrogenase in all experimental mice were detected. Results： All patients with disulfiram-like reaction were cured by dexamethasone. The activity of acetaldehyde dehydrogenase in treatment group was significantly higher than that of the other groups （P〈0.05） . Conclusions： The disulfiram-like reaction can be relieved by dexamethasone quickly, which may be due to the raised activity of acetaldehyde dehydrogenase induced by dexamethasone.
出处
《内科急危重症杂志》
2008年第4期205-206,共2页
Journal of Critical Care In Internal Medicine
关键词
地塞米松
治疗
双硫仑样反应
临床研究
实验研究
Dexamethasone
Disulfiram-like reaction
Treatment
Clinical study
Experimental study
作者简介
通讯作者：刘非凡，E-mail：whzyyjzk@126.com
