摘要
目的探讨洋葱伯克霍尔德菌医院感染的耐药性及其变迁,为临床合理用药提供依据。方法对医院2004年1月-2006年12月住院患者各种标本中分离到的洋葱伯克霍尔德菌859株,采用22种抗菌药物进行药敏试验。结果氨苄西林、氨苄西林/舒巴坦、阿莫西林/克拉维酸、头孢唑林、庆大霉素、妥布霉素、阿米卡星、亚胺培南、呋喃妥因的耐药率均>90.00%;耐药率较低的有头孢他啶(23.57%)、头孢吡肟(26.95%)、环丙沙星(31.73%)、头孢哌酮/舒巴坦(33.33%)、哌拉西林/他唑巴坦(21.45%);最敏感的是复方新诺明,总耐药率仅5.73%。结论医院感染洋葱伯克霍尔德菌的临床检出率呈逐年上升趋势,且对多种抗菌药物具有耐药性,应加强监测,根据药敏试验选用合理抗菌药物。
OBJECTIVE To investigate the change in antibiotic resistance of Burkholderia cepacia in hospital for reference of clinical antimicrobial strategy. METHODS Data were collected of the 859 bacteria strains isolated from clinical specimens from Jan 2004 to Dec 2006. Drug sensitivity tests were made for 22 antimicrobial agents. RESULTS All of the drug-resistance rates were higher than 90.00% including ampicillin, ampicillin/sulbactam, amoxicillin/clavulanic acid, cefazolin, gentamicin, tobramycin, amikacin, imipenem and nitrofurantoin, but that of the others such as ceftazidime（23.57%）, cefepime（26.95%）, ciprofloxacin（31.73%）, cefoperazone/sulbactam （33.33%）, and piperacillin/tazobactam （21. 45%） were lower. The resistance rate to sulfamethoxazole/ trimethoprim was 5.73% which was the lowest. CONCLUSIONS The isolation rate as well as the resistance to most of the antibiotics are increasing in clinical specimens. Antimicrobial treatment should be guided by drug sensitivity test.
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2008年第8期1164-1166,共3页
Chinese Journal of Nosocomiology
关键词
洋葱伯克霍尔德菌
医院感染
耐药性
Burkholderia cepacia
Nosocomial infection
Drug resistance
