摘要
目的:通过对苓丹痛风康胶囊抗痛风作用的研究,探讨该药的药效及作用机制,为临床应用提供依据。方法:口服给药,运用二甲苯致小鼠耳廓肿胀法观察其抗炎作用;运用醋酸扭体法观察其镇痛作用;运用酵母膏致小鼠高尿酸血症法观察其对尿酸、黄嘌呤氧化酶、尿素氮的影响;结果:苓丹痛风康胶囊有明显的抗炎、镇痛、降低高尿酸血症小鼠血尿酸的作用,并能抑制黄嘌呤氧化酶活性、降低血尿素氮。结论:苓丹痛风康胶囊具有抗痛风性关节炎的作用。
Objective： To provide foundation for clinical application through studying the drug action and mechanism of action of Lingdantongfengkang Capsule on anti-gout effects. Methods： Lingdantongfengkang Capsule was taken orally. The experimental methods were as follow： mouse ear swell induced by dimethylbenzene, mouse pain induced by injecting acidum aceticum in abdominal cavity, mouse hyperuricemia model induced by yeast. Results： Lingdantongfengkang Capsule could lessen mouse ear swell induced by dimethylbenzene, decreae mouse stretching frequencies induced by injecting acidum aceticum in abdominal cavity and antagonize animal serum uric acid, liveness of xanthinoxidase and urea nitrogen induced by yeast to mice.Conclusion： Lingdantongfengkang Capsule possesses the anti-gout effects.
出处
《中华中医药杂志》
CAS
CSCD
北大核心
2008年第8期742-744,共3页
China Journal of Traditional Chinese Medicine and Pharmacy
关键词
苓丹痛风康胶囊
痛风
疾病模型
实验研究
Lingdantongfengkang Capsule, Gout, Disease model, Experimental study
作者简介
通讯作者：高学敏，北京市朝阳区北三环东路11号北京中医药大学68信箱，邮编：100029，电话：010-64286993 E-mail：zylab208@163．com
