摘要
目的研究病毒载量检测在鉴别诊断HIV早期感染中的应用。方法对13份HIV抗体检测结果高度提示为早期感染的样本进行病毒载量检测，并对这些个体进行随访和抗体检测以证实其感染状况。结果13份样本中，有12份病毒载量阳性，随访确定1例HIV抗体阳性婴幼儿感染者，11例窗口期感染者；1例HIV抗体呈阳性的婴幼儿，病毒载量阴性，随访证实未感染。病毒载量检测结果与最终的感染状况相符。结论通过病毒载量检测能够有效鉴别诊断早期感染中的婴幼儿感染（18个月以内抗体呈阳性）和窗口期感染者。病毒载量检测可以作为HIV感染早期不确定样本的诊断依据。
Objective To study the application of viral load for differentiating diagnosis of early HIV infection. Methods Thirteen indeterminate specimens, which showed early HIV infection of antibody detection, were selected. Viral load of the specimens were detected. People with suspicious infection were followed up and certified infection status through EIA and Western blot. Results Twelve of 13 indeterminate specimens which indicated early HIV infection, had positive viral loads. One antibody-positive infant was confirmed to have been infected by HIV and 11 recent infected （window period） persons were certified during the follow-up. One antibody-positive infant had negative viral load and was certified noninfected person during the follow-up. Viral load testing results accorded with HIV infection status. Conclusion Viral load testing can be used to diagnose HIV early infection, including antibody-positive infants （within 18 months ） and recent infected persons. Viral load testing could be diagnostic rule of indeterminate specimens during early HIV infection.
出处
《中华微生物学和免疫学杂志》
CAS
CSCD
北大核心
2008年第6期557-559,共3页
Chinese Journal of Microbiology and Immunology
作者简介
通讯作者：黑发欣，Email：heifx@bjcdc．org，电话：010-64407366
