期刊文献+

阿司匹林抵抗 被引量:1

原文传递
导出
摘要 阿司匹林广泛用于防治心、脑血管疾病,成为最常用的抗血小板药物之一。由于其有效的抗血小板聚集作用,所以阿司匹林在冠心病的二级预防以及某些选择性患者的一级预防中具有重要价值。然而,部分患者服用阿司匹林后并不能获得均一的抗血小板效果,未能达到预防和治疗作用,存在明显的个体差异。这种现象被称为阿司匹林抵抗(aspirin resistance,AR)。本文就阿司匹林抵抗的定义、分类、发生机制以及对策等方面作一综述。
作者 刘宏宇
出处 《中国基层医药》 CAS 2008年第4期689-690,共2页 Chinese Journal of Primary Medicine and Pharmacy
  • 相关文献

参考文献19

  • 1Gum PA, Kottke MK, Poggio ED, et al, Profile and prevalence of aspirin resistance on patients with cardiovascular disease. Am J Cordial, 2001,88:230-235.
  • 2韩文忠,郭华,杨宝刚.阿司匹林、氯吡格雷对冠心病心力衰竭治疗的影响[J].中国医药,2006,1(3):138-139. 被引量:15
  • 3Weber ZZ, Zimmermann KC, Meyer-Kirehrath J, et al. Cyclooxygenase-2 in human platelets as a possible factor in aspirin resistance. Lancet, 1999,353:900.
  • 4Weber AA, Przytulski B, Schumacher M, et al. Flow eytometry analysis of platelet cyclooxygenase-2 expression: induction of platelet eyelooxygenase-2 in patients under-going Coronary artery bypass grafting. Br J Haematol,2002,117(2) :424-426.
  • 5Rocca B, Secchiero P, Ciabattoni G, et al. Cyclooxyge-nase-2 expression is induced during human megakaryo-poiesis and characterizes newly formed platelets. Proc Natl Acad Sci USA, 2002,99 : 7634-7639.
  • 6Catella-Lawson F, Reilly MP, Kapoor SC, et al. Cyclooxygenase inhibitors and the antiplatelet effects of aspirin. N Engl J Med, 2001,345 (25) : 1809-1817.
  • 7Cryer B, Berlin RG, Cooper SA, et al. Double-blind, randomized, parallel, placebo-controlled study of ibuprofen effects on thromboxane B2 concentrations in aspirin-treated healthy adult volunteers. Clin Ther,2005,27(2) :185-191.
  • 8Kong DF. Aspirin in cardiovascular disorders. What is the optimum dose?. Am J Cardiovasc Drugs,2004,4(3) : 151-158.
  • 9Helgason CM, Tortorice KL, Winkler SR, et al. Aspirin response and failure in cerebral infarction. Stroke, 1993,24 (3):345-350.
  • 10Antithrombotic Trialists' Collaboration. Collaborative meta-analysis of randomised trials of antiplatelet therapy for prevention of death, myocardial infarction, and stroke in high risk patients. BMJ ,2002,324(7329) :71-86.

二级参考文献2

共引文献14

同被引文献14

  • 1郝卫军,司全金,李小鹰.老年心血管疾病患者应用不同剂量阿司匹林抗血小板治疗的临床研究[J].中国临床保健杂志,2006,9(3):210-212. 被引量:4
  • 2孙武,岳永焕,孙彩艳.心内科门诊使用阿司匹林情况的调查[J].中国基层医药,2007,14(6):1022-1023. 被引量:1
  • 3Antithrombotic Trialists′ Collaboration.Collaborative meta-analysis of randomised trials of antiplatelet therapy for prevention of death,myocardial infarction,and stroke in high risk patients[J].BMJ,2002,324(7329):71-86.
  • 4The SALT Collaborate Group.Swedish Aspirin Low-dose Trial(SALT)of 75mg Aspirin as secondary prophylaxis after cerebrovascular ischemic events[J].Lancet,1991,338(8779):1345 -1491.
  • 5Patrono C,Coller B,FitzGerald GA,et al.Plaelet-active Drugs:The relationships Among Dose,Effectiveness,and Side Effect.The Seventh ACCP Conference on Antithrombotic and Thrombolytic Therapy[J].Chest,2004,126suppl3:234-264.
  • 6Krasopoulos G,Brister SJ,Beattie WS,et al.Aspirin "resistance" and risk of cardiovascular morbidity:systematic review and meta-analysis[J].BMJ,2008,336(7637):195-198.
  • 7Michelson AD,Frelinger AL III,Furman MI.Current options in platelet function testing[J].Am J Cardiol,2006,98(10A):4-10.
  • 8Michelson AD.Flow cytometry assessment of glycoprotein movements in Platelets[J].Platelets,1997,8(2):105-115.
  • 9Abrams C,Shattil SJ.Immunological detection of activation platelets in clinical disorder[J].Thromb Haemost,1991,65(5):467-650.
  • 10杨维维,唐海沁.阿司匹林在心血管疾病中的应用进展[J].中国临床保健杂志,2007,10(5):535-538. 被引量:2

引证文献1

二级引证文献8

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部