摘要
目的观察早期康复治疗加用依达拉奉治疗急性脑梗死(ACI)的疗效。方法采用随机对照试验,选择发病48h内的ACI患者68例,随机分为依达拉奉治疗组(34例)及对照组(34例),治疗前后定期对患者进行神经功能缺损评定,日常生活活动能力(ADL)评定,神经功能缺损评定采用美国国立卫生院卒中量表(NIHSS),ADL评定采用Barthel指数量表,以治疗第21天NIHSS和ADL改变作为主要疗效判断标准。应用SPSS10.0软件进行统计学处理。结果21d后治疗组、对照组NIHSS相比差异有显著性(P<0.05);两组ADL相比差异有显著性(P<0.01),治疗组无明显不良反应。结论早期康复治疗基础上加用依达拉奉是一种改善急性脑梗死患者神经功能缺失的有效治疗方案,值得进一步评价。
Objective To evaluate efficacy of Edaravone and early rehabilitation on acute cerebral infarction（ACI）. Methods Performed a randomized controlled study on ACI patients. 68 patients,enrolled within 48 h of onset,were allocated to Edaravone group（ n = 34） and control group （ n = 34） randomly. Before and after treatment, the neurological deficits and activities of daily living（ADL） were assessed using national institute of health stroke scale（NIHSS） and Barthel Index respectively. Clinical efficacy was evaluated according to changes of NIHSS and ADL scores between two groups on the 21th day. Results There was a significant difference of NIHSS scores between Edaravone group and the control group（P 〈 0.05）on the 21th day. There was also a significant difference of ADL scores between Edaravone group and the control group（P 〈 0. 01 ）. No distinct adverse reaction was observed in Edaravone group. Conclusion Edaravone combining with early rehabilitation therapy is an effective method of improving the neurological function impairment of acute cerebral infarction patients, being worthy of further evaluation.
出处
《中国实用医药》
2008年第3期16-17,共2页
China Practical Medicine
关键词
依达拉奉
急性脑梗死
早期康复
Edaravone
Acute cerebral infarction
Early rehabilitation
