摘要
目的:建立多成分药物代谢网络动力学数学模型,并对参数进行初步分析。方法:采用线性动力学方法建模,用拉氏变换法求解,研究多成分代谢网络动力学数学模型与参数的关系,并对多成分代谢网络动力学模型中各参数的求算进行初步分析。结果:药物多成分代谢网络动力学遵循一级线性乳突模型,c_i为e的幂指数多项式形式,与总室模型相似,各参数(转运常数)由其与各室间常数构成矩阵的特征值α_i的关系方程组算得。其动力学参数可在总室模型的基础上求算。结论:多成分代谢网络动力学各参数与总室一样可求得。
AIM： To establish a network pharmacokinetic model for studying multiple drug components and analyzing their parameters. METHODS： A model has been set up based on the compartment and linear kinetic theories, and the solutions have been obtained by Laplace transform method. The relations between the whole compartment model and network model for multiple component have been comparatively studied and their kinetic parameters have also been estimated and analyzed. RESULTS： The multiple component network pharmacokinetics follow a first order linear mammillary model. Ci is a polynomial of power index number e, which is similar to the whole compartment model. Various parameters（transit constant） were calculated by the expression of matrix consisting of αi and the compartment parameters. Its kinetic parameters can be obtained on the basis of the whole compartment model. CONCLUSION： The multiple component network pharmacokinetic parameters can be obtained and analyzed similarly as the whole compartment model.
出处
《中国临床药理学与治疗学》
CAS
CSCD
2007年第12期1321-1331,共11页
Chinese Journal of Clinical Pharmacology and Therapeutics
基金
国家自然科学基金(30472199)博士后基金(20070410997)资助。
关键词
多成分代谢网络动力学
总室模型
数学模型
拉民变换
药物动力学
KEY WORDS multiple component network pharmaco-kinetics
whole compartmental model
mathematical model
Laplace transform
pharmacokinetics
作者简介
贺福元，男，中南大学临床药理所博士后，合作导师周宏灏院士。主持和承担国家自然科学基金课5项；发表专业性论文60余篇，专著2部。国际中医药专业中药专业组成员，国际中药药剂学专业理事。本人研究方向：中药药剂学，中医药信息数学，遗传中药药理学；创立了中药复方药物及提取谱动学；中药复方指纹图谱分析新方法；总量统计矩法；中医药学科现代化研究方法。Tel：0731-5381372 E-mail：pharmsharking@tom．com
