摘要
目的:探讨男性原发无精子症和少精子症与Y染色体无精子症因子(AZF)微缺失的关系。方法:应用多重PCR技术对原发无精子症(24例)和少精子症(19例)患者基因组DNA进行Y染色体连锁的6个序列标签位点缺失分析。结果:43例患者中检出有Y染色体微缺失4例,缺失率为9.3%,其中无精子症3例,少精子症1例。结论:Y染色体微缺失是原发无精子症和少精子症的重要原因之一,对原发无精子症和少精子症患者进行Y染色体微缺失的常规筛查是有必要的。
Objective： To evaluate the relationship between Y chromosome azoospermia factor（AZF） microdeletion and idiopathic azoospermia/oligospermia in males. Methods： Multiplex PCR was used to detect Y chromosome deletion in 43 idiopathic azoospermia/oligospermia patients （24 idiopathic azoospermia patients, 19 idiopathic oligospermia patients）. Results： Y chromosome AZF microdeletion was found in 4 patients and the rate of deletions was 9.3%. Among the 4 cases, 3 cases were with azoospermia and 1 case was with oligospermia. Conclusion ： Y chromosome deletion is one of the important factors of idiopathic azoospermia/oligospermia. It is necessary to carry out the routine screening of Y chiromosome microdeletion to the idiopathic azoospermia/oligoseprmia patients
出处
《中国计划生育学杂志》
北大核心
2007年第11期682-684,共3页
Chinese Journal of Family Planning
关键词
原发无精子症
原发少精子症
无精子症因子
微缺失
Idiopathic azoospermia
Idiopathic oligospermia
Azoospermia factor
Microdeletion
