摘要
喹诺酮类抗生素是人工合成萘啶酸衍生物,通过抑制DNA旋转酶的活性杀死细菌的,因其有抗菌谱广、吸收好、血液浓度高、能迅速分解到各组织、半衰期长、能制成各种剂型等特点而得到迅速推广。但喹诺酮抗生素对人体有一定的副作用。目前该类药物已被广泛应用于家禽家畜的疾病防治中,因而肉类和蛋类中的喹诺酮药物残留量已引起人们的广泛关注。欧共体国家(EU)早在20世纪90年代就对肉类中喹诺酮类抗生素的最大残留量进行了限制。由此产生很多喹诺酮类抗生素多残留的分析方法。本文主要介绍了喹诺酮类药物的种类、应用、不良反应,以及各种残留分析方法,主要包括高效液相法(HPLC)以及与此相关的HPLC-UV、HPLC-FD、HPLC-DVD、LC-MS-MS,LC-ESI-MS-MS;另外还有荧光光谱法、毛细管电泳法和酶联免疫法等。
Quinolones bactericides are artificial nalidixic acids derivates which can kill bacterias by inhibiting their DNA-gyrase. They were widely applied because of their good absorbability, long half life and so on. But they have side effects on human, So now people paid much attention to quinolones residues in meat and eggs since quinolones had been often used in livestock and fishfarm industries. Therefore, the European Union（EU） has set tolerance levels for these compounds as maximum residue limits （MRLs） in 1990s. At present the common determination methods are also HPLC and other correlative methods, for example, HPLC-UV, HPLC-FD, LC-MS-MS. In addition, there are also Fluorescence spectrometry, CE and ELISA which are common determination methods for quinolones residues as well.
出处
《食品科学》
EI
CAS
CSCD
北大核心
2007年第11期628-633,共6页
Food Science
作者简介
李雅丽（1982-），女，硕士研究生，研究方向为兽药残留。
通讯作者
