1Kingma PS, Burden DA, Osheroff N, et al. Binding of etoposide to topoisomerase Ⅱ in the absence of DNA: decreased affinity as a mechanism of drug resistance [ J ]. Biochemistry, 1999,38 ( 12 ): 3457.
2Lavasani LS, Hiasa H. A parE-parC fusion protein is a functional topoisomerase [ J ]. Biochemistry, 2001,40: 8438.
3Fortune JM, Dickey JS, Lavrukhin OV, et al. Site-specific DNA cleavage by chlorella virus topoisomerase Ⅱ [ J]. Biochemistry ,2002,41:11761.
4Robinson MJ, Martin BA, Gootz TD, et al. Effects of novel fluoroquinolones on the catalytic activities of eukaryotic topoisomerase Ⅱ:influence of the C-8 fluorine group [ J]. Antimicrob Agents Chemother,1992,36:751.
5Strumberg D, Nitiss JL, Dong JW, et al. Importance of the fourth alpha-helix within the CAP homology domain of type Ⅱ topoisomerase for DNA cleavage site recognition and quinolone action [ J]. Antimicrob Agents Chemother, 2002,46:2735.
6Gilligan PJ, McGuirk PR, Witty MJ. Antibiotic derivatives of 7-phenyl-1, 4-dihydro-4-oxo-3-quinolinecarboxylic acids [ P ] . US,A61K, 4623650,1986-11-18.
7Bromberg KD, Burgin AB, Osheroff N. Quinolone action against human topoisomerase IIR: stimulation of enzyme-mediated double-stranded DNA cleavage [J]. Biochemistry ,2003,42:3393.
8Clement JJ, Burres N, Jarvis K, et al. Biological characterization of a novel antitumor quinolone[J]. Cancer Research,1995,55:830.
9Kim MY, Duan WH, Gleason GM, et al. Design, synthesis, and biological evaluation of a series of fluoroquinoanthroxazines with contrasting dual mechanisms of action against topoisomerase Ⅱ and G-quadruplexes [J].J Med Chem, 2003,46:571.
10Chen YL, Fang KC, Sheu JY, et al. Synthesis and antibacterial evaluation of certain quinolone derivatives [J] . J Med Chem, 2001,44:2374.
