摘要
[目的]了解市售的染发剂的慢性毒性作用。[方法]采用动物实验观察不同剂量染发剂对豚鼠肝脏的影响。[结果]染发剂对豚鼠体重增加有影响;可引起肝脏肝细胞索紊乱,肝血窦不清,肝细胞水肿,弥漫性水样变性、坏死等病变,对照组与染发剂浓度为50﹪、100﹪组肝脏病理改变差异有统计学意义(H=22.46,P﹤0.001)。[结论]≥50﹪浓度的染发剂可导致豚鼠肝脏发生病理改变,并能影响动物的生长发育。
To understand the chronic toxicity of commercial hair dye.[Methods]Guinea pigs were used to do animal experiments to observe the effects of different doses.[Results]The weight gain of guinea pigs was influenced by hair dye;it could also bring about disorders of liver cells arrangement,hepatic sinusoids unclear,liver cells edema,diffusely swelling degeneration,necrosis lesions and so on;the differences of pathological changes of liver were statistically significant between the control group and 50%,100% concentration groups.[Conclusion]The dyes with the concentration of and above 50% can cause pathological changes on guinea pigs＇ liver,and can affect the growth and development of animals.
出处
《现代预防医学》
CAS
北大核心
2007年第21期4084-4084,4091,共2页
Modern Preventive Medicine
关键词
染发剂
肝细胞
豚鼠
Hair dye,Liver cells,Guinea pigs
作者简介
陈治群（1952-），高级实验师，研究方向：环境卫生
叶运莉，Email：wushuangyewu@163．com
