摘要
直肠内黏膜血管丰富,有利于药物在全身的循环,并能部分避免首过效应导致的肝代谢。直肠给药制剂具有快速吸收,无痛等优点,有时可作为静脉给药的替代和补充。本文比较了常用直肠给药栓剂、灌肠液、凝胶剂和泡沫剂的优缺点,以期为临床用药提供参考。
Mucosal surfaces of recta are rich in blood supply, providing the means for rapid drug transport to the systemic circulation and avoiding, in most cases, degradation by first-pass hepatic metabolism. Rectal adminis- tration provides rapid absorption of many drugs and may be an easy alternative way to the intravenous route, hav- ing the advantage of being relatively painless. This statement describes four forms of rectal administration inclu- ding suppository, enema, gel, foam, in order to improve the ability of physicians to manage specific problems.
出处
《药学与临床研究》
2007年第5期344-346,共3页
Pharmaceutical and Clinical Research
关键词
直肠给药
栓剂
灌肠剂
凝胶剂
泡沫剂
比较
Rectal administration
Suppository
Enema
Gel
Foam
Comparison
作者简介
王明丽，女，副主任药师Tel：0519-86609223E-mail：wangminglicz@163．com
