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针灸足三里穴对衰老模型小鼠皮肤中MDA、GSH-Px和Hyp的影响 被引量:10

Influence of Point Zusanli Acupuncture and Moxibustion on Dermal MDA,GSH-Px and Hyp in A Mouse Model of Senility
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摘要 目的观察了针灸足三里穴对衰老小鼠皮肤组织形态的影响。方法长期颈背部皮下注射D-半乳糖造成小鼠亚急性衰老模型,随机分为针刺组、艾灸组、模型组和空白组,检测皮肤组织中丙二醛(MDA)含量、谷胱甘肽过氧化物酶(GSH-Px)活力、羟脯氨酸(Hyp)含量。结果针灸足三里穴能够使衰老模型小鼠皮肤组织中的MDA含量减少,GSH-Px活力增强,Hyp含量增多。结论针灸足三里穴对小鼠皮肤衰老具有拮抗作用。 Objective To investigate the influence of point Zusanli (ST 36) acupuncture and moxibustion on dermal histomorphology in senility mice. Methods A mouse model of subacute senility was made by long-term nape subcutaneous injection of D-galactose. The mice were randomly allocated to acupuncture, moxibustion, model and blank control groups. Dermal malondialdehyde (MDA) content, glutathione peroxidase (GSH-Px) activity and hydroxyproline (Hyp) content were measured. Results Point Zusanli acupuncture and moxibustion could decrease dermal MDA content, heighten GSH-Px activity and increase Hyp content in a mouse model of senility. Conclusion Point Zusanli acupuncture and moxibustion has an antagonistic effect on mouse skin senility.
出处 《上海针灸杂志》 2007年第10期39-40,共2页 Shanghai Journal of Acupuncture and Moxibustion
基金 江苏省高校国家重点实验室培育点针药结合实验室资助
关键词 针灸疗法 足三里 D半-乳糖 皮肤衰老 Acupuncture and moxibustion Point,Zusanli D-galactose Skin senility
作者简介 杨春英(1980-),女,2004级硕士生,主要研究方向为针灸治疗损容性疾病;E-mail:yangchunying@163.com.
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  • 1李文彬,韦丰,范明,张京立,张炳烈,马向晨,杨卫平,魏文.D-半乳糖在小鼠上诱导的拟脑老化效应[J].中国药理学与毒理学杂志,1995,9(2):93-95. 被引量:170
  • 2Chung JH, Seo JY, Choi HR, et al. Modulation of skin collagen metabolism in aged and photoaged human skin in vivo. J Invest Dermatol, 2001, 117: 1218-1224.
  • 3Frolkis VV. Aging, anti-aging, ontogenesis and periods of age development. Gerontology,1999, 45: 227-232.
  • 4刘培辉.病理染色技术(第2版)[M].北京:人民卫生出版社,2000.56-61.

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