摘要
目的在高胆固醇饮食致家兔动脉粥样硬化(atherosclerosis,AS)的基础上,研究厄贝沙坦对AS及脂质过氧化的影响。方法18只雄性家兔随机分成3组:正常组(A组)饲喂普通饲料,动脉粥样硬化组(B组)饲喂高胆固醇饲料,治疗组(C组)饲喂高胆固醇饲料并给予厄贝沙坦治疗,对已形成AS的主动脉作病理学检查并测定丙二醛(MDA)、超氧化物歧化酶(SOD)等脂质过氧化指标。结果厄贝沙坦使AS斑块面积减小,动脉内膜厚度减低,同时使AS家兔血清及动脉组织MDA降低、SOD升高。结论厄贝沙坦通过抑制脂质过氧化发挥防治AS的作用。
Objective To study the effect ofirbesartan on the developement of aortic athemsclerosis and the level of lipid peroxidation in rabbits fed with a high cholestcol diet. Methods 18 rabbits were divided into 3 groups： group A given a normal chow; group B given a high cholesterol diet; group C given the high cholesterol diet and 75mg/kg.d ofirbesartan. The progression of atherosclerosis was assessed by gross pathology and histopathology, and the levels of MDA and SOD in serum and arterial wall were measured. Results The treatment with irbesartan reduced atherosclerostic area and intimal depth of aorta, reduced the level of MDA and increased the level of SOD. Conclusion Irbesartan has the effect ofanti-atherosclerosis through suppression of lipid peroxidation.
出处
《医学新知》
CAS
2007年第5期275-276,279,共3页
New Medicine
作者简介
干学东，男，主治医师：武汉大学中南医院心血管内科（430071）
