摘要
目的比较匹伐他汀与阿托伐他汀治疗缺血性卒中患者的疗效及安全性。方法选取2017年10月-2018年9月天津医科大学总医院滨海医院接诊的100例缺血性卒中患者为研究对象,采用随机数字表法分为对照组和观察组,各50例。对照组采用阿托伐他汀治疗,观察组采用匹伐他汀治疗,比较两组临床治疗总有效率、血脂指标、NIHSS评分、血肌酐、尿素氮、白细胞计数、血小板计数、尿蛋白阳性率。结果观察组治疗总有效率为86.00%,高于对照组的82.00%,差异无统计学意义(P>0.05);两组LDL-C、TG、TC均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);两组NIHSS评分均低于治疗前,差异有统计学意义(P<0.05),但组间比较,差异无统计学意义(P>0.05);观察组血肌酐、尿素氮、白细胞计数、尿蛋白阳性率均低于对照组,血小板计数高于对照组,差异有统计学意义(P<0.05)。结论匹伐他汀与阿托伐他汀对缺血性卒中疗效相似,但匹伐他汀降低血脂水平更显著,且可一定程度缓解药物不良反应,具有一定的临床应用优势。
Objective To compare the efficacy and safety of pitavastatin and atorvastatin in the treatment of ischemic stroke.Methods A total of 100 patients with ischemic stroke admitted to Binhai Hospital,General Hospital of Tianjin Medical University from October 2017 to September 2018 were selected as the study subjects.They were divided into control group and observation group by random number table method,with 50 cases in each group.The control group was treated with atorvastatin,and the observation group was treated with pitavastatin.The total effective rate,blood lipid index,NIHSS score,serum creatinine,urea nitrogen,white blood cell count,platelet count and urine protein positive rate were compared between the two groups.Results The total effective rate of the observation group was 86.00%,which was higher than 82.00%of the control group,and the difference was not statistically significant(P>0.05).The levels of LDL-C,TG and TC of the two groups were lower than those before treatment,and those in the observation group was lower than the control group,the difference was statistically significant(P<0.05).NIHSS scores of the two groups were lower than those before treatment,and the difference was statistically significant(P<0.05),however,there was no significant difference between groups(P>0.05).The positive rates of serum creatinine,urea nitrogen,white blood cell count and urinary protein in the observation group were lower than those in the control group,and the platelet count was higher than that in the control group,the difference was statistically significant(P<0.05).Conclusion The efficacy of pitavastatin and atorvastatin in the treatment of ischemic stroke is similar,but pitavastatin reduces blood lipid levels more significantly,and can alleviate adverse drug reactions to a certain extent,which has certain clinical application advantages.
作者
王跃慧
李春彦
WANG Yue-hui;LI Chun-yan(Department of Neurology,Binhai Hospital,General Hospital of Tianjin Medical University,Tianjin 300480,China;Department of Cardiology,the Second Affiliated Hospital of Hebei North University,Zhangjiakou 075100,Hebei,China)
出处
《医学信息》
2022年第8期150-152,共3页
Journal of Medical Information
作者简介
王跃慧(1979.9-),女,河北平山县人,本科,副主任医师,主要从事神经内科疾病的诊治工作。
