摘要
目的:观察原发性高血压、高血压合并心肌肥厚及血管重构患者血浆尾加压素Ⅱ(urotensinⅡ,UⅡ)含量的变化,探讨UⅡ在高血压病发生发展过程中的意义。方法:选择原发性高血压患者67例(高血压组),和正常人34例(正常对照组),应用超声方法检测颈动脉内-中膜厚度(IMT)、左室重量指数(LVMI),并将原发性高血压患者分为单纯性高血压组,高血压合并血管重构组及合并心肌肥厚组,采用放射免疫分析法检测血浆UⅡ含量。结果:高血压组患者血浆UⅡ含量(5.14±2.59)pg/ml,明显低于正常对照组(6.75±1.55)pg/ml及单纯性高血压组(6.54±2.00)pg/ml,P<0.01。而单纯性高血压组与正常对照组比较无显著差异,P<0.05。较之正常对照组,血管重构组患者IMT,心肌肥厚组患者LVMI、IMT明显增加;这两组血浆UⅡ含量明显减少,亦明显少于单纯性高血压组,分别为(5.08±2.47)pg/ml,P<0.05;(3.85±1.97)pg/ml,P<0.05;并且血浆UⅡ水平与IMT、LVMI呈显著的负相关(分别为r=-0.506,P<0.01;r=-0.399,P<0.01)。结论:UⅡ可能在高血压病血管重构及心肌肥厚的过程中有重要作用,但作用机制及其意义有待深入研究。
Objective, To investigate the correlation among urotension Ⅱ level and hypertension, myocardial hypertrophy, blood vessel reconstruction. Methods： （1） Selecting hypertensive patient 67 samples （essential hypertension group）, normal healthy volunteers 34 samples （control group）. Peripheral venous blood was collected in EDTA from patients and control subjects, and then plasma was collected after being centrifuged. UⅡ levels in plasma were determined by radiommunoassay. （2） Intima-media thickness （IMT） of carotid artery and left ventricular mass index （LVMI） were measured by ultrasonography in 101 patients with essential hypertension and 50 normotensive controls. Dividing all patients with hypertension into simple hypertension group, hypertension complicated with blood vessel reconstruction group and complicated myocardial hypertrophy group. Results： （1） The mean plasma UⅡ level in normal control group was （6.75±1.55） pg/ml. In patients with hypertension, the mean plasma UⅡ level was （5.14±2. 59） pg/ml, which was significantly lower than normal control group （P〈0.01） and simple hypertension group （6.54±2.00） pg/ml, P〈0. 01, there was no significant differences in mean plasma UⅡ level between simple hypertension group and control group （P〉0. 05） ; （2） IMT and LVMI increased in hypertension subjects complicated with blood vessel reconstruction group and complicated myocardial hypertrophy group compared with control group. The mean plasma UⅡ level in blood vessel reconstruction group and myocardial hypertrophy group was significantly lower than those of control group and simple hypertension group respectiyely （5.08±2. 47） pg/ml, （3.85±1.97） pg/ml, P〈0.05 all. There were negative relation among UⅡ and IMT, LVMI （ r= -0. 506, P〈0.01 ; r= -0. 399, P〈0.01, respectively）. Conclusion： The UⅡ may participate in the pathophysiological process of myocardial hypertrophy and the blood vessel reconstruction.
出处
《心血管康复医学杂志》
CAS
2007年第5期428-431,共4页
Chinese Journal of Cardiovascular Rehabilitation Medicine
基金
2007年北京朝阳区科委项目(SF0705)
