摘要
目的 :研究冠心病、原发性高血压、糖尿病及骨质疏松症患者血浆尾加压素Ⅱ(urotensinⅡ ,UⅡ)水平的变化 ,以探讨UⅡ在上述疾病过程中的意义。方法 :清晨空腹抽血 ,分离血浆 ,采用放射免疫分析法检测血浆UⅡ含量。结果 :健康人血浆UⅡ含量为 5 .5 4± 1.73pg/ml;稳定性心绞痛和急性心肌梗塞患者血浆UⅡ水平分别为 2 .74± 0 .9和 2 .85± 0 .99pg/mg ,明显低于健康人 (均为p<0 .0 1) ,并且急性心肌梗塞患者在发病两周内 ,血浆UⅡ水平持续低于健康人 (p<0 .0 1)。 2型糖尿病和原发性高血压患者也有所降低 (分别为 4.98± 1.97和 4.89± 1.6 8pg/ml,p <0 .0 5 ) ,而骨质疏松症患者无明显变化 (p >0 .0 5 )。结论 :稳定性心绞痛、急性心肌梗塞、原发性高血压以及糖尿病患者 ,血浆UⅡ含量降低 ,提示UⅡ可能在其病理生理过程中发挥着十分重要的作用 。
Objective To investigate changes of plasma urotensin Ⅱ (UⅡ) levels in patients with coronary heart disease, non-insulin-dependent diabetes (NIDD), essential hypertension (EH) and osteoporosis, and to study the pathophysiological roles of UⅡ in these diseases. Methods Peripheral venous blood was collected in EDTA from normal healthy volunteers and patients, the blood was then centrifuged and plasma was collected, UⅡ levels in plasma were determined by radioimmunoassay. Results The mean plasma UⅡ level in control group was 5.54±1.73 pg/ml. In patients with stable angina pectoris (SAP), actue myocardial infarction (AMI), NIDD and EH, the mean plasma UⅡ level were 2.74±0.9 pg/ml, 2.85±0.99 pg/ml, 4.98±1.97 pg/ml and 4.89±1.68 pg/ml respectively, which were significantly lower than that in control group ( p <0.01 in SAP and AMI group, p <0.05 in NIDD and EH group respectively). Furthermore, the mean plasma UⅡ level in patients with AMI remained significantly lower than that in control group from 6 h to 2 weeks after myocardial infarction. But there were no significant differences between patients with osteoporosis and controls. Conclusion The plasma UⅡ levels in patients with NIDD, EH, SAP and AMI were decreased significantly and this suggests that UⅡ might participate in the pathophysiological process of the diseases.
出处
《放射免疫学杂志》
CAS
2001年第4期195-197,共3页
Journal of Radioimmanology
关键词
尾加压素Ⅱ
放射免疫分析
高血压
冠心病
病理
urotensin Ⅱ, radioimmunoassay, essential hypertension, coronary heart disease
