摘要
目的:探讨p63在乳腺良、恶性疾病中的表达及意义。方法:收集乳腺良、恶性疾病的石蜡包埋标本50例(纤维腺瘤,纤维囊性病,导管内乳头状瘤,导管内癌,浸润性导管癌和浸润性小叶癌)采用免疫组化S-P法检测p63在上述病变中的表达。结果:在乳腺良性病变中几乎所有的腺体外周都见完整的p63阳性的肌上皮围绕;在导管内癌中,部分导管外围可见完整的p63阳性的肌上皮围绕(24%),部分导管外周p63阳性的肌上皮细胞则呈间断性分布(62%),甚至无肌上皮细胞(14%);在浸润性癌的癌细胞巢外周未见p63阳性的肌上皮细胞。结论:p63作为肌上皮细胞的标记物有助于在疑难的乳腺病变中正确识别肌上皮细胞,鉴别良恶性病变。
Objective ：To study the role of p63 in differential diagnosis of epithelial benign and malignant breast lesions. Methods： We collected 50 eases of breast benign and malignant paraffin-embedded samples（ineluding fibroadenoma ,fibrocystie diseases, intraduetal papilloma,intraduetal eaieinoma,invasive duetal carcinoma and invasive lobular eareinoma）,and detected the expression of p63 in above breast lesions by immunohistoehemistry.Results：In breast benign lesions, almost all of the glands were encircled by p63 positive cells. In intraduetal carcinoma,some cancer cell nests（24%） showed continuous positive cells in their circumference;other showed discontinuous or even no positive cells （62% and 14% respectively） .There were no p63 positive cells in invasive carcinomas. Concluslon：As a marker of myoepithelial ceUs,p63 could help to recognize myoepithelial cells correctly in confusing breast lesions and differentiate epithelial benign from malignant breast lesions.
出处
《现代医药卫生》
2007年第22期3341-3342,共2页
Journal of Modern Medicine & Health
