摘要
目的:探讨载有鹿茸多肽(VAP)的乙交酯与丙交酯共聚物(PLGA)纤维对吻合后鸡趾鞘管区屈肌腱愈合和防粘连的效果。方法:健康来亨鸡48只,雌雄各半,随机分成4组,每组12只。将家鸡左足趾浅屈肌腱切除,趾深屈肌腱横断,改良Kessler法缝合,A组为对照:肌腱吻合后不进行处理;B、C和D组分别在吻合处包裹PLGA纤维、低剂量(质量比为0.3%)VAP/PLGA和高剂量(质量比为1.5%)VAP/PLGA纤维。术后2、3、4周取材,分别进行大体观察,组织学检查,生物力学实验。结果:A组粘连严重,其余各组肌腱粘连程度无明显差异,C、D组肌腱断裂张力增强,与A、B组比较差异有显著性意义(P<0.05)。结论:VAP/PLGA纤维能减轻肌腱术后粘连、促进肌腱愈合,是理想的生物降解组织修复重建材料。
Objective： To investigate the effect of poly （lactide-co-glycolid） （PLGA） fibers containing Velvet Antler Peptide （VAP） on tendon repair and reconstruction. Method： Forty-eight Leghorn chickens were divided into four groups randomly, 12 in each group. The chickens of group A were served as blank controls, group B were used PLGA fibers, group C and group D were used low （0.3%, w/w） and high （1.5%, w/w） dose VAP/PLGA fibers, respectively. The superficial and profundus flexor tendon of the second, third and fourth toes were cut and sutured with a single 6-0 nylon stitch by modified Kessler technique, and were not wrapped （Group A） or wrapped with PLGA fibers（Group B）, low dose（Group C） and high dose（Group D） VAP/PLGA fibers, respectively. The specimens were evaluated by microscope, transmission electron microscope and mechanical tensile measurements. Result： The specimens in group A showed more serious adhesions than others groups. Tendons in group C and D had bigger strain than those in group A and group B. Conclusion： As biodegradable materials, VAP/PLGA fibers could prevent tendon adhesion and promote tissue repair and reconstruction.
出处
《中国康复医学杂志》
CAS
CSCD
北大核心
2007年第9期796-798,共3页
Chinese Journal of Rehabilitation Medicine
作者简介
徐效义，男，博士，助理研究员
通讯作者：景遐斌（中国科学院长春应用化学研究所高分子物理与化学国家重点实验室，长春，130022）
