摘要
丝裂原活化蛋白激酶(MAPK)家族广泛存在于高等生物中,介导多种生物学进程,在固有免疫防御中发挥重要作用,是真核细胞抵御病原菌侵染的第一道防线.越来越多的研究发现,病原菌可以利用多种方式激活或者抑制MAPK信号通路来增强其自身侵染力.简单介绍了MAPK信号通路的背景并详细总结了近几年关于病原菌如何作用于MAPK信号通路的研究工作,希望以此能够拓展对病原菌与宿主细胞作用方式的认识,深化对MAPK重要作用的了解.
MAPK （mitogen- activated protein kinase） family, which is conserved throughout high eukaryotes, is implicated in multiple cellular processes including cell growth, migration, proliferation, differentiation, survival and development. Pathogen hijacks hosts＇ MAPK pathways to facilitate its pathogenesis using diverse strategies. To further explore the mechanism underlying interactions between pathogens and hosts＇ MAPK pathway, is of benefit to our understanding of nature as well as to our fight against pathogen infection.
出处
《生物化学与生物物理进展》
SCIE
CAS
CSCD
北大核心
2007年第9期906-914,共9页
Progress In Biochemistry and Biophysics
作者简介
通讯联系人．Tel：010-80726688-8560，Fax：010-80728046 E-mail：shaofcng@nibs．ac．cn
