摘要
目的评价应用碘化油及四氧化三铁（Fe3O4）微球栓塞治疗原发性巨块型肝癌的临床疗效。方法回顾分析行超选择插管栓塞原发性巨块型肝癌246例,分两组,以碘化油6-27 ml＋Fe3O4250μm,丝裂霉素（10 mg）,5-Fu 250 mg混悬液栓塞,主干应用明胶海绵栓塞126例,选择同期常规剂量碘化油及明胶海绵治疗巨块型肝病120例作为对照组,碘化油用量6-27 ml,分析两组术前后病灶大小变化,近期有效率及生存率。结果碘化油及Fe3O4组近期有效率明显高于碘化油组,碘化油及Fe3O4组1、2、3年生存率分别为89.3%、42.7%、31.2%,而碘化油组分别为53.8%、14.9%、12.6%。结论碘化油及Fe3O4微球治疗巨块型肝癌较碘化油栓塞组疗效有明显提高,可视为治疗巨块型中晚期肝病的有效方法。
Objective To study the clinical effect of treating metaphase and advanced primary massive hepatic carcinoma with intra-hepatic artery chemotherapy and embolizing therapy. Methods Retrospectively analyzed the data of 246 patients with primary massive liver carcinoma who were treated by intra-hepatic artery chemotherapy and embolizing therapy. These patients were randomly divided into two groups： one group （treatment group,126 cases） was embolized by iodinated oil （6 -27 ml）, ferrosoferric oxide （250 μm）, mitomycin （10 mg） and 5 Fluorouracil （250 mg）, and the stem of hepatic artery were embolized with gelatin sponge. The other one （control group, 120 cases） was treated by iodinated oil （6-27 ml） and gelatin sponge only. Then compared the size of the tumor, the effective rate and the survival rate in near future between these two groups. Results The effective rate in near future of the treatment group is higher than that of the control group. The survival rate in 1, 2 and 3 years was 89.3%, 42.7%, and 31.2% respectively in treatment group, and in the control group, the number was 53.8 %,14.9 %, and 12.6 % respectively. Conclusion Compared with single embolizing therapy, combining the intra-hepatic artery chemotherapy with embolizing therapy can increase the effective rate and survival rate in near future significantly. This method is effective in treating the metaphase and advanced primary massive liver carcinoma.
出处
《中国介入影像与治疗学》
CSCD
2007年第4期266-268,共3页
Chinese Journal of Interventional Imaging and Therapy
关键词
肝动脉
肝肿瘤
放射摄影术
介入性
Hepatic artery
Liver neoplasms
Radiography, interventional
作者简介
王家平（1971-），男，云南腾冲人，博士，副教授。研究方向：介入放射学。E-mail：jpwang12@hotmail．com [通讯作者]王家平，昆明医学院第二附属医院放射科，650101。
