摘要
目的：了解恶性上皮性肿瘤c-kit基因蛋白表达分布及其意义。方法：回顾我院及南京军区福州总医院2005-08～2006-08共634例外科手术切除病检标本，免疫组化检测CD117在恶性上皮性肿瘤表达。结果：CD117阳性癌症患者共16例。胃肠道癌8例，其中1例为复发性癌，乳腺癌6例，肺癌2例。结论：少数恶性上皮性肿瘤c-kit基因蛋白表达，可能提示部分恶性上皮性肿瘤的格列卫用药指征。
Objective：To know about the Expression and implication of c-kit gene in malignancy epithelial tumor, Methods：634 cases of malignant tumour specimens that had been stained with immunohistochemistry method in routin were collected from the second people hosipital of Fujian province and Fuzhou general hospital of Nanjing command from Aug,E005 to Aug,E006. The positive expression of CDll7 were observed and analyzed on malignancy epithelial tumor. Results：CD117 were positive on 16 cases of malignancy epithelial tumor, of which 8 cases were gastrointestinal tract cancer, 6 cases of breast cancer and 2 cases of lung cancer. Concluslon：The expression of c-kit gene is present on a few malignancy epithelial tumor and may suggest an indication of lmatinibmesylate （ST1571） .
出处
《中国误诊学杂志》
CAS
2007年第15期3446-3448,共3页
Chinese Journal of Misdiagnostics
关键词
肿瘤
腺和上皮
诊断
原癌基因蛋白质C-KIT
分析
免疫组织化学
Neoplasms, glandular and epithelial/diagnosis
Proto-oncogene protein c-kit/analysis
lmmunohis-tochemistry
作者简介
高尤亮（1977-），男，河南罗山县人，住院医师，硕士。研究方向：消化道肿瘤。
