摘要
通过给小鼠灌胃Na2SeO3,观察了0.025、0.05和0.1 mg/kg剂量的硒被应用后对小鼠血清中细胞因子IL-2、IL-6和TNF-α水平的影响,结果表明,硒能明显降低正常小鼠血清中的IL-2及TNF-α水平,且呈剂量依赖关系;对IL-6水平则有显著的升高作用,即呈正相关。该结果提示,微量元素硒对细胞因子水平有显著的调控作用。
Changes of levels of IL-2, IL-6 and TNF-α in sera of mice were observed after the mice were treated with different doses Se of 0. 025 mg/kg, 0.05 mg/kg and 0.1 mg/kg respectively. Results were as follows. Se had functions to decrease the level of IL-2 in a dose dependent manner and lower the level of TNF-α significantly, and on the contrary the level of IL-6 significantly. The results showed that Se can enhance immune functions and adjust the levels of Cytokines in mice.
出处
《中国畜牧兽医》
CAS
2007年第6期98-100,共3页
China Animal Husbandry & Veterinary Medicine
基金
中国农业科学院兰州畜牧与兽药研究所基金项目(MYJJ05-2)
作者简介
荔霞（1977-），女，甘肃人，助理研究员，硕士生，主要从事动物营养代谢病及免疫研究。
