摘要
针对目前文献中报道的2-羟基-4,6-二甲基嘧啶盐酸盐的合成存在加料繁琐、收率低等问题,我们在合成时对加料方式、反应过程、产物分离三方面做了改进,简化了加料过程,相同条件下收率提高了10%。对改进后的方法进行了参数优化,65℃时反应48h收率达91.3%。
Synthesis of 2-hydroxyl-4,6-dimethyl pyrimidine was studied. The procedures reported in the literature were complicated and the field was low. The feeding procedure for reacting compounds ,reaction conditions and product separation were improved and simplified for the above reaction process. The proper parameters were optimized. The product yield was 91.3% under comditions ： reaction time 48h at 65℃ ,which was increased by 10%.
出处
《化学研究与应用》
CAS
CSCD
北大核心
2007年第6期703-705,共3页
Chemical Research and Application
作者简介
舒远杰（1969-），研究员，博导，主要从事含能材料及精细化学品制备与性能研究,Email：syjfree@sohu.com
