摘要
为了寻找高效、安全的杀菌活性化合物,设计并合成了8个N-(4,6-二取代嘧啶-2-基)苯甲酰胺类化合物,其化学结构经1HNMR、IR、LC/MS和元素分析确证。初步生物活性测定结果表明,该类化合物具有一定的杀菌活性,当浓度为25mg/L时,化合物4g对稻瘟病菌Pyricularia oryzae的抑制率达85.1%,化合物4f对小麦赤霉病菌Gibberella zeae的抑制率达92.9%。
In search of safer and more effective fungicidal compounds, eight N-（4, 6-disubstitued pyrimidin-2-yl）-benzamides were designed and synthesized. Their structures were confirmed by IR, ^1H NMR, LC/MS and elemental analysis. Preliminary bioassay showed that some of the title compounds showed good fungicidal activity, for example, 4g exhibited 85. 1% inhibition rate to Pyricularia oryzae at 25 mg/L and 4f exhibited 92.9% inhibition rate to Gibberella zeae at 25 mg/L.
出处
《农药学学报》
CAS
CSCD
2007年第1期76-79,共4页
Chinese Journal of Pesticide Science
基金
国家自然科学基金资助项目(20372021).
关键词
2-氨基嘧啶
苯甲酰胺
合成
杀菌活性
2-aminopyrimidine
benzamide
synthesis
fungicidal activity
作者简介
黄明智（1967-），男，通讯作者，研究员，从事新农药创制研究．联系电话：0731-5959096；E—mail：huang-mz@163．com
