摘要
研究羧甲基壳聚糖水凝胶(CMCS-GA)对阿司匹林的吸附性能及其在药物控释系统中的应用。以羧甲基壳聚糖作为骨架材料,采用戊二醛交联法制备CMCS-GA,进而制备阿司匹林载药凝胶。测定凝胶在人工肠液中的溶胀动力学特点,观察载药凝胶在人工肠液中的体外释放行为。在pH=7.4的人工肠液中CMCS-GA 2 h达最大溶胀度1.38。CMCS-GA的载药量为4.6 mg/g,凝胶在人工肠液中96 h的累积释放度为99.91%,具有优良的缓释性能,药物的体外释放模型符合一级动力学方程。
The object of this study was to evaluate the adsorption capability of CMCS-GA to aspirin and its application in drug release-controlled systems. CMCS-GA based on CMS were prepared by cross-linking with glutaraldehyde, then aspirin entrapped hydrogel was prepared by the adsorption effect of CMCS-GA to aspirin. The swelling characteristics and the release behaviors of aspirin entrapped hydrogel in simulated intestinal juice （pH = 7.4） have been studied respectively. CMCS-GA in the simulated intestinal juice （pH = 7.4） reached the maximum swelling degree 1.38 in 2 h. The adsorbing capacity of aspirin by CMCS-GA was 4.6 mg/g, the cumulated release rate of aspirin entrapped hydrogel in the simulated intestinal juice （pH = 7.4） for 96h was 99.91%, which indicated the excellent release-controlled capability of the aspirin entrapped hydrogel. The results also showed that the release profile of aspirin from hydrogel followed first order kinetic equations.
出处
《中国海洋大学学报（自然科学版）》
CAS
CSCD
北大核心
2007年第3期503-506,共4页
Periodical of Ocean University of China
关键词
壳聚糖
戊二醛
缓释凝胶
体外释放度
chitosan
GA
release-controlled hydrogel
drug releasing in vitro
作者简介
徐甲坤（1984-），男，硕士生。E—mail：chenfeng858652@163．com
通讯作者：E—mail：bcfeng@ouc．edu．cn
