摘要
醛固酮合成酶基因(CYP11B2)部分位点的多态性改变除导致血浆醛固酮水平发生改变外,还与血糖变化密切相关。作者除对醛固酮传统的水钠滞留导致容量性血压升高外,还参与或介导了血管紧张素Ⅱ的部分靶器官损伤作用,与糖尿病及其慢性并发症的发生和进展有关作一综述,并对醛固酮受体拮抗剂在糖尿病慢性并发症中的治疗意义进行了分析与讨论。
Several genetic polymorphisms of the aldosterone synthase gene （CYP11B2）, which may influence the plasma aldosterone levels, had been reported to influence the blood glucose levels. In addition to the effects of sodium （ and consequently water） resorption and potassium excretion, aldosterone could be involved in the development and progression of diabetes and its chronic complications. This paper also discussed the therapeutic significance of aldosterone receptor antagonists on the occcurance of chronic diabetic complications.
出处
《医学研究生学报》
CAS
2007年第5期548-552,共5页
Journal of Medical Postgraduates
基金
南京医科大学发展基金资助项目(批准号:NY04059)
关键词
醛固酮
醛固酮受体拮抗剂
糖尿病
慢性并发症
Aldosterone
Aldosterone receptor antagonist
Diabetes
Chronic complications
作者简介
王霞娟（1972-），女，江苏江阴人，主治医师，医学硕士，从事内分泌专业。
