摘要
目的观察金刚藤分散片(JDT)对大鼠慢性盆腔炎(CPID)血流变与病理组织形态学的影响。方法选用SPF级SD雌性大鼠48只,采用在大鼠子宫一侧注入25%苯酚胶浆诱发的大鼠CPID模型,保留8只仅开腹不造模为假手术组对照,造模组7 d后随机分为5组:模型组、金刚藤胶囊(JC)组、金刚藤分散片(JDT)低、中、高剂量组。灌胃给药治疗,1 m l/(100 g/d),连续14 d。实验结束后取血进行血流变学检测,取子宫肉眼观察后进行病理组织学检查。结果JDT可显著改善造模大鼠血液流变学的各项指标;JDT组大鼠子宫内膜病理组织形态学较模型组有显著改善,且JDT中、高剂量组均优于JC组。结论JDT对大鼠CPID有理想治疗作用。
Objective To study the effect of Jingangteng dispersible tablet（JDT） on chronic pelvic inflammatory disease （CPID） in the blood rheology and pathological histology of rat. Methods Forty-eight female SD rat of SPF＇class were chosen and injected 25% phenol glue into one side of their uterus to induce CPID models. Control group was reserved as a comparison of fake operation by just openning their abdomens without injecting the phenol glue. Seven days later the operated group was randomly divided into five groups ： the model group, the Jingangteng capsule （JC） group and the treating groups （ different dosages of JDT ）, 1 ml/（ 100 g/d ）, continuous 14 days,intragastric administration. After the experiment, the blood rheology was measured and the uterus were observed by naked eyes and the endometria pathological histology was checked. Results Compared with the model rat, the data of the blood rheology and the degree of the endometria pathological histology of the JDT groups were significantly improved ; the middle and high dosage group of JDT were all more excellent than the JC group in treatment. Conclusion JDT is promising on treating CPID in rat.
出处
《现代食品与药品杂志》
2007年第2期38-41,共4页
JOurnal of Modern Food and Pharmaceuticals
关键词
金刚藤分散片
慢性盆腔炎
血液流变学
大鼠子宫病理组织形态学
Jingangteng dispersible tablet
chronic pelvic inflammatory disease
blood rheology
endometria pathological histology of rat
作者简介
向海燕（1975-），女，在读硕士，主治医生，从事药剂与理学评价及临床医疗工作。
