期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

7-对甲氧基苯基-9-甲基-1,6-二氮杂螺[4,4]壬酮的晶体结构 被引量：1

Crystal structure of 7-(4-methoxyphenyl)-9-methyl-1,6-diazaspiro nonan-1-one
在线阅读 下载PDF
导出
摘要 用X射线衍射法测定了标题化合物7-对甲氧-基苯基-9-甲基-1,6-二氮杂螺[4,4]壬酮(C15H20N2O2)的晶体结构,该晶体属三斜晶系:空间群为Pī;晶胞参数a=1.039 09(9)nm,b=1.084 54(10)nm,c=1.351 45(16)nm,β=76.502(7)°;V=1.410 8(2)nm3,Z=2;Dx=1.226 mg/m3,F(000)=560.最终偏离因子R=0.063 3,wR2=0.182 9. The crystal structure of the title compound C15H20N2O2 was reported. The crystal belongs to the Triclinic system, space group PT with the unit cell parameters： a = 1. 039 09 （9） nm, b = 1. 084 54 （10） nm, c = 1. 351 45（16） nm, β = 76. 502（7）°; V = 1. 410.8（2） nm^3, Z = 2, Dx = 1. 226 mg/m^3, F（000）=560. The final factors R1 = 0. 063 3, ωR2 = 0. 182 9.
作者 徐显秀 刘景林
机构地区 东北师范大学化学学院
出处 《东北师大学报（自然科学版）》 CAS CSCD 北大核心 2007年第1期138-140,共3页 Journal of Northeast Normal University(Natural Science Edition)
基金 国家自然科学基金资助项目(20602006) 东北师范大学青年基金资助项目(111494090)
关键词 氮杂螺环γ-内酰胺 晶体结构 键长 键角 spiro-γ-lactam crystal structure bong length bong angle
分类号 O621 [理学—有机化学]
作者简介 徐显秀（1975-），男，博士，讲师，主要从事有机合成化学研究．
  • 相关文献

参考文献8

  • 1BRUCKDORFER T,MARDER O,ALBERICIO F.From production of peptides in milligram amounts for research to multi-tons quantities for drugs of the future[J].Curr Pharm Biotechnol,2004(5):29-43.
  • 2GENIN M J,OJALA W H,GLEASON W B,et al.Synthesis and crystal structure of a peptidomimetic containing the (R)-4.4-spiro lactam type-Ⅱ.beta.-turn mimic[J].J Org Chem,1993,58:2 334-2 337.
  • 3FERNANDEZ M M,DIEZ A,RUBIRALTA M,et al.Spirolactams as conformationally restricted pseudopeptides:synthesis and conformational analysis[J].J Org Chem,2002,67:7 587-7 599.
  • 4GENIN M J,GLEASON W B,JOHNSON R L.Design,synthesis,and X-ray crystallographic analysis of two novel spirolactam systems as beta-turn mimics[J].J Org Chem,1993,58:860-866.
  • 5BRANA M F,GARRANZO M,PASCUAL-TERESA B,et al.Chemoselective michael reactions on pyroglutamates.expeditious synthesis of spiro-bis-γ-lactams as β-turn peptidomimetics[J].Tetrahedron,2002,58:4 825-4 836.
  • 6XU X,CHE X,SHU G,et al.Synthesis of aza/oxaspiro-γ-lactams by radical translocation cyclization reactions[J].Synlett,2005,12:1 865-1 868.
  • 7邵允,李春霞,朱东升,刘群.新型Cd(Ⅱ)配合物的合成及晶体结构[J].东北师大学报（自然科学版）,2005,37(3):45-48. 被引量：6
  • 8马春宏,王仁章,郭东刚,刘春玲,林雪,徐吉庆.梯形(phen)Zn—O—MoO_2晶体的水热合成与表征[J].东北师大学报（自然科学版）,2006,38(1):59-62. 被引量：6

二级参考文献28

  • 1李晓萍,刘巨涛,金向军.钒取代磷钨酸VO(phen)_2^(2+)配合物的合成、表征及生物活性[J].东北师大学报（自然科学版）,2005,37(2):55-58. 被引量：2
  • 2邵允,李春霞,朱东升,刘群.新型Cd(Ⅱ)配合物的合成及晶体结构[J].东北师大学报（自然科学版）,2005,37(3):45-48. 被引量：6
  • 3Cabaleiro S,Va'zquez-Lo'pez E, Castro J, et al.Cadmium(Ⅱ) complexes with[(4-methylphenyl)sulfonyl]-2-pyridyl-amine:crystal structures of bis{[(4-methylphenyl)sulfonyl]-2-pyridyl-amide}cadmium(Ⅱ);aquo-bis(pyridine) bis{[(4-methylphenyl)sulfonyl]-2-pyridyl-amide}cadmium(Ⅱ) and 1,10-phenanthroline bis{[(4-methylphenyl)sulfonyl]-2-pyridyl-amide}cadmium(Ⅱ)[J].Inorganica Chimica Acta, 1999, 294:87-94.
  • 4Goher M A S,Mautner F A,Hafez A K,et al.Two new polymeric cadmium(Ⅱ) complexes containing end-to-end bridging azido or thiocyanato ligands with different topologies[J].Polyhedron, 2003, 22: 975-979.
  • 5Al-Ktaifani M M,Francis M D,Hitchcock P B,et al.Synthesis,crystal and molecular structures of pyridine adducts of the zinc and cadmium bis-1,2,4-triphospholyl complexes[M(η1-P3C2'Bu2)2(NC5H5)n](M=Zn, n=2;M=Cd,n=3)[J].Journal of Organometallic Chemistry,2001,633:143-148.
  • 6Goher M A S,Mautner F A,Abu-Youssef M A M,et al.Structural characterization of one-,two-, and three-dimensional polymeric complexes assembled by cadmium(Ⅱ) pseudohalides and some pyridine ligands via covalent bonds and hydrogen bonds[J].Polyhedron, 2003,22:3 137-3 143.
  • 7Luo Junhua,Hong Maochun,Weng Jibao,et al.The complexes with end-to-end dicyanamide bridges:syntheses,characterization and crystal structures of[Cu(μ1,5-dca)2(phen)]n and[Cd(μ1,5-dca)2(py)2]n(phen=phenanthroline;PY=pyridine;DCA=dicyanamide, N(CN)2-[J].Inorganica Chimica Acta,2002,329:59-65.
  • 8Reger D L, Wright T D, Smith M D. Mixed-ligand complexes of cadmium(Ⅱ) containing bulky polydentate nitrogen-based ligands Inorganica Chimica Acta[J].2002,334:1-9.
  • 9Wenjun Zheng, Xi Liu,Junhuai Guo,et al.Preparation and crystal structure of two novel cadmium (Ⅱ)-trimesates, Cd(HTMA)(NC5H5)2·0.5CH3OH·0.5DMF and Cd(HTMA)·2H2O[J].Inorganica Chimica Acta,2004,357:1 571-1 578.
  • 10Joseph B K, Verghese B, Sudarsanakumar C,et al. Highly facile and stereoselective intramolecular[2+2]photocycloadditions of bis(alkenoyl)ketenedithioacetals[J].Chem Commun,2002(7):736-737.

共引文献8

同被引文献7

  • 1MITSUYA H,WEINHOLD K J,FURMAN P A,et al.3-Azido-3-deoxythymidine(BW A509U):3'-Azido-3'-deoxythymidine (BW A509U):an antiviral agent that inhibits the infectivity and cytopathic effect of human t-lymphotropic virus type Ⅲ/lymphadenopathy-associated virus in vitro[J].Proc Natl Aead Sci U S A,1985,82(20):7096-7100.
  • 2BALZARINI J.Effect of antimeta bolite drugs of nucleotide metabolism on the anti-human immunodeficiency virus activity of nucleoside reverse transcriptase inhibitors[J].Pharmacol Ther,2000,87(2-3):175-187.
  • 3LAMBERT J S,SEIDLIN M,REICHMAN R C,et al.2',3'-dideoxyinosine(ddl)in patients with the acquired immunodefi-eieney syndrome or AIDS-related complex.A phase I trial[J].N Engl J Med,1990,322(19):1333-1340.
  • 4KIM H O,AHN S K.ALVES A J,et al.Asymmetric synthesis of 1,3-dioxoIane-pyrimidine nucleosides and their anti-HIV activity[J].J Med Chem,1992,35(11):1987-1995.
  • 5JEONG L S,SCHINAZI R F,BEACH J W.et al.Asymmetric synthesis and biological evaluation of β-L-(2R,5S)-and a-L-(2R,5R)-1,3-oxa-thiolane-pyrimidine and purine nueleosides as potential anti-HIV agents[J].J Med Chem,1993,36(2);181-195.
  • 6BERNARD BELLEAU,LIVIO BRASILli,LAVVAL CHAN,et al.A novel class of 1,3-oxathiolane nueleoside analogues hay-ing potent anti-HIV activity[J].Innorganie & Medicinal Chemistry Letters.1993,3(8):1723-1728.
  • 7SHELDRICK G M.SHEL XL-97,a program for structure refinement[CP].University of Gobttingen,Gottingen,Germany,l997.

引证文献1

东北师大学报（自然科学版）
2007年 第1期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
关于我们 | 版权声明 | 联系我们 | 帮助中心| 意见反馈
主办单位：上海市教育委员会
技术支持：重庆维普资讯有限公司
渝公网安备 50019002500403号
使用帮助 返回顶部