摘要
目的制备姜黄素自微乳化浓缩液,考察微乳的形态和粒径分布,比较姜黄素微乳与胶束的吸收动力学,考察姜黄素微乳在小肠的最佳吸收及口服姜黄素自微乳化浓缩液在胃肠道的吸收情况。方法采用大鼠在体小肠段回流试验,根据药物在小肠段中的减少量来确定药物的吸收。取出小鼠胃肠道中所有内容物及粪便,提取未被吸收的姜黄素,计算姜黄素的吸收率。结果透射电镜下姜黄素微乳成球形或近球形,平均粒径为21.6nm。姜黄素微乳与胶束的吸收速率常数分别为0.0425、0.0195/h,姜黄素微乳的主要吸收部位为十二指肠和空肠。姜黄素自微乳化浓缩液在小鼠胃肠道的吸收率是姜黄素原料药的2.5倍。结论姜黄素自微乳化浓缩液能有效提高姜黄素在动物体内的吸收。
Objective To prepare the curcumin self-microemulsion, observe the morphology and size diameter distribution of the microemulsion, and compare the absorption kinetics of curcumin microemulsion and micelle. To investigate the best absorption segment of curcumin microemulsion in intestnum tenue and the absorption of curcumin self-microemulsion in mouse gastrointestinal tract. Methods The intestine in rats was cannulated in situ recirculation. The absorption of curcumin microemulsion was calculated by its decrement in intestnum tenue. The inabsorbable curcumin in all content together with feces in mouse gastrointestinal tract was obtained and used to calculate the absorption rate of curcumin. Results The curcumin microemulsion presented as small spherical drops or something similar under transmission electron microscope （TEM） with the average diameter of about 21.6 nm. The absorption constants of curcumin microemulsion and micelle was 0. 042 5 and 0. 019 5 /b , the main segments of curcumin microemulsion absorption were intestinum duodenum and intestinum jejunum. The absorption rate of curcumin self-microemulsion was 2.5 times as much as curcumin. Conclusion The curcumin self-microemulsion could improve the absorption of curcumin in vivo in animal evidently.
出处
《中草药》
CAS
CSCD
北大核心
2007年第3期368-372,共5页
Chinese Traditional and Herbal Drugs
基金
山东省科技发展计划资助项目(2006GG22020563)
关键词
姜黄素
自微乳化
在体小肠吸收
curcumin
self-microemulsion
in situ absorption in intestnum tenue
作者简介
崔晶（1980-），女，山东济南人，硕士，药师，从事药物制剂与临床药学研究。E—mail：cccjjjrrr@sina．com
通讯作者 翟光喜 Tel：（0531）6820872 E—mail：zkyjd@sdu.edu.cn
