摘要
APTES-bounded MNP were prepared by chemical coprecipitation,followed by coating with((γ-aminopropyl))triethoxysilane.Norvancomycin hydrochloride(Van) was then immobilized onto the amino-functionalized nanopartiles.Powder X-ray diffraction(XRD) results show the inverse spinel structure of MNP.The physics property measurement system(PPMS) indicates that the MNP are superparamagnetic.The presence of Van and APTES on the surface of MNP is confirmed by FTIR.By a separation assay of S.aureus and E.coli BL21,it is proved that MNP-APTES-Van can selectively capture S.aureus within 10 min,which can be isolated readily by applying an external magnetic field.
APTES-bounded MNP were prepared by chemical coprecipitation, followed by coating with （y-aminopropyl） triethoxysilane. Norvancomycin hydrochloride （Van） was then immobilized onto the aminofunctionalized nanopartiles. Powder X-ray diffraction（XRD） results show the inverse spinel structure of MNP. The physics property measurement system （PPMS） indicates that the MNP are superparamagnetic. The presence of Van and APTES on the surface of MNP is confirmed by FTIR. By a separation assay of S. aureus and E. coli BL21, it is proved that MNP-APTES-Van can selectively capture S. aureus within 10 min, which can be isolated readily by applying an external magnetic field.
出处
《高等学校化学学报》
SCIE
EI
CAS
CSCD
北大核心
2007年第1期26-28,共3页
Chemical Journal of Chinese Universities
基金
教育部霍英东基金优选资助项目(批准号:J20040212)资助
关键词
磁性纳米粒子
万古霉素
生物缔合
细菌分离
Magnetite nanoparticles
Vancomycin
Bioconjugate
Bacterial separation
作者简介
计剑（1969年出生），男，博士，教授，主要从事生物医用高分子、介入医用材料和组织工程材料的研究．E-mail：jiaji@mail．hz．zj．cn
