摘要
目的：筛选预防急性高原反应的药物。方法：随机选择来自西宁周边地区（低于海拔2260m）青壮年男性筑养路工人94名，分为服药组（A组、B组和C组）和安慰剂对照组（D组）。服药组分别服用复方1号、复方2号及复方3号中药复方制剂。受试者乘车于（2～3）天急进海拔4600m以上施工现场，各组启程时开始服药。每天早、中、晚3次，每次3片（粒），连续服药3周。在到达海拔4600m以上施工现场后，分别于第1天、第3天、第7天、第15天进行急性高原反应评分调查。结果：组间比较后发现：急进后第1天和第15天，D组分值均高于其他3组，但无统计学差别；第3天时，仅有A组分值高于D组，差别无显著性；第7天仍是D组高于其他3组，其中A、B两组与D组差别存在显著性（P〈0．05）。组内比较后发现：A组第1天和第3天、第7天、第15天均存在非常显著性差别（P〈0．01）、第3天和第15天差别非常有显著性（P〈0．05）；B组第1天和第15天、第3天和第15天差别均有非常显著性（P〈0．01）；C组第1天和第3天、第7天、第15天差别均有非常显著性（P〈0．01）；D组仅第1天和第15天差别非常有显著性，第1天和第3天、第7天、第15天差别均有非常显著性（P〈0．01）。各组不同时间的急性高原反应分度中，无重度反应出现。药物不良反应仅有少数人出现轻度腹泻症状。结论：3种抗缺氧复方药物对降低急性高原反应均有效，不良反应少而轻微。复方2号优于复方1号和复方3号。
Objective： To observe the difference effects of three anti--hypoxic traditional Chinese medi- cine, Co--I, Co--II and Co--III, on prevention of the acute high altitude response. Methods： 94 young healthy roadmen from Xining area （low level of 2 260m altitudes） were randomI.y divided into the four groups. Group A, B, C were given Co--Ⅰ, Co--Ⅱ, Co--Ⅲ for 3 weeks respectively before exposing high altitude, 3 capsules/time, 3/d （morning, midday and evening） ; group D served as the control group. The acute mountain sickness symptoms were recorded by cores on the first, third, seventh and fifteenth day of arrival high altitude. Results： The scores on the first and fifteenth day in the group D were higher than those in other three groups （P〈0. 05）. The scores on the third day in group A were higher than that in group D （P〉0. 05）. Again on the seventh day, the scores in group D were higher than ones in the group A, B （P〈0. 05） and group C. There was a significant difference of cores （P〈0. 01） between the 1st day and the third as much the seventh and 15th day in group A or C. There was a significant difference （P〈0. 01）between the first and 15th day and P〈0. 05 difference between the seventh or fifteenth day in the group B. A significant difference only existed between the first and fifteenth day in the control group. Conclusions： The three compound anti--hypoxic drugs have better effects for improvement of the acute high altitude response and mild untoward responses. The results suggest that the Co--Ⅱ is priority to the Co--Ⅰ and Co--Ⅲ drug on the anti--hypoxic effect.
出处
《高原医学杂志》
CAS
2006年第4期8-11,共4页
Journal of High Altitude Medicine
基金
<高原(山)地区筑养路职工安全与健康保障研究>为西部地区交通建设科技项目(编号:44000128-5
由交通部及青海省交通厅资助)。
关键词
急进高原
抗缺氧药物
急性高原反应
预防
Anti--hypoxic drug
High altitude
Acute high altitude response
Prevention
