摘要
目的:观察复方甘草酸苷联合咪唑斯汀对泛发性神经性皮炎(GND)疗效及对患者心理因素的影响。方法:将60例GND患者随机分成治疗组(复方甘草酸苷联合咪唑斯汀)与对照组(咪唑斯汀),疗程均为28d,用焦虑自评量表(SAS)进行治疗前、后心理因素有关项目测定,比较2组临床疗效和患者心理因素的变化。结果:治疗组与对照组治疗后的SAS总分分别为(30.53±1.50)分、(33.20±1.67)分(P<0.01),总有效率分别为90.0%、74.3%(P<0.001)。结论:复方甘草酸苷联合咪唑斯汀治疗GND起效快、止痒效果好,能明显改善焦虑情绪,阻断瘙痒-搔抓-心理障碍间的循环。
OBJECTIVE： To evaluate the therapeutic effect of compound glyeyrrhizin plus mizolastine for patients with generalized neurodermatitis（GND） and its influence on patietents＇ psychology.METHODS： 60 patients with GND were randomly assigned to receive compound glycyrrhizin plus mizolastine（treatment group） or mizolasitine alone（control group） for 28 days.The psychological factors were examined before and after treatment using self rating anxiety scale（SAS）,and the curative effects and the psychological changes between two groups were compared .RESULTS： The SAS scores of treatment group and control group were 30.53 ± 1.50 and 33.20 ± 1.67, respectively（ P 〈 0.01）, and t he effective rates were 90.0 % and 74.3 %, respectively（P〈0.001） .CONCLUSION： Compound glycyrrhizin in combination with mizolastine shows a quick and satisfactory itching relieving effect on generalized neurodermatitis,and it can markedly improve anxiety and prevent the vicious cycle of itching scratching- psychological disorder.
出处
《中国药房》
CAS
CSCD
北大核心
2006年第24期1893-1895,共3页
China Pharmacy
作者简介
副主任医师，副教授。研究方向：过敏性皮肤病。电话：027—62112560。E—mail：arzt@tom．com
