摘要
目的 分析和探讨体外受精-胚胎移植（IVF—ET）周期最合适的获卵数目。方法 对上海集爱遗传与不育诊疗中心2005实施的短方案有获卵的共963个IVF-ET新鲜周期进行回顾性总结和分析，根据不同获卵数分为4组（A组：1—5，B组：6～15，C组：16～25及D组：〉25个卵子），就各组的周期数、年龄、平均促性腺激素（Gn）用量及天数、HCG注射日的E2值、全冻胚胎数、放弃周期数、种植率和临床妊娠率进行分析。结果 （1）获卵数随年龄增加呈下降趋势。（2）周期完成率在6～15个卵子组最高；A组因缺乏有效胚胎移植，周期放弃率较高；其余3组随获卵数增加，为预防OHSS行胚胎全冻而放弃移植的周期比例也随之明显上升（P〈0．01）。（3）Gn用药天数各组差异无显著性，P〉0．05。（4）Gn用量随获卵数增加呈下降趋势，呈负相关，差异有显著性（P〈0．05）；（5）注射HCG日的血清E2值随获卵数增加而明显上升，与获卵数呈正相关，各组之间差异有显著性（P〈0．01）；（6）种植率（IR）及妊娠率（PR）在B组及D组较A组及C组高，但差异无显著性（P〉0．05）。结论 适量促性腺激素超促排后的获卵数，在移植有效胚胎数相同的条件下，获卵数多少与其妊娠率差异并无显著意义，但就总体IVF-ET结局而言，短方案IVF—ET周期中获卵数在6～25个之间有较理想的妊娠结局。
Objective To investigate the suitable range of retrieved oocytes number in in vitro fertilization - embryo transfer （IVF-ET） cycle. Methods A retrospective analysis was performed on 963 IVF ET cycles with GnRH-a flare-up protocol between January 1 2005 through to December 31 2005. Total of 963 cycles were divided into four groups depending on retrieved oocyte number： A： 1 -5, B： 6 -15, C： 16 -25 and D： 〉25 oocytes. Results （1） The number of retrieved oocytes was negatively related to age. （2）The lowest cycle cancellation rate between 6 - 15 oocytes; Cycle can- cellation rate in group A was high because of no valued embryo available for transfer;for the other three groups ,with the increase of retrieved oocytes number, the cancellation rate for frozen was up because of the tendency to OHSS. （3） No difference in duration of gonadotrophin （Gn） stimulation within four groups. （4） Average dosage of Gn was negative related to retrieved oocytes number, also showing a dose-related pattern, P 〈0.05. （5） Number of retrieved oocytes was positively related to serum Ez levels on the day of hCG administration, P 〈0. 01. （6） The implantation and pregnancy rates in group B and group D were higher than those in group A and C, P 〉 0. 05. Conclusion Considering the overall outcome of IVF-ET, the number of retrieved oocyte is between 6 - 25 for good pregnancy outcome in IVF-ET cycle.
出处
《中国实用妇科与产科杂志》
CAS
CSCD
北大核心
2006年第12期927-929,共3页
Chinese Journal of Practical Gynecology and Obstetrics
作者简介
E-mail： huachen7@ yahoo.com
