摘要
目的：初步探讨中药仙鹤草提取物的镇痛抗炎作用。方法：取仙鹤草的水提取物和乙醇提取物,应用醋酸致小鼠扭体法、小鼠热板法、二甲苯致小鼠耳廓肿胀法和大鼠角叉菜胶足跖肿胀法研究其镇痛抗炎作用。结果：仙鹤草乙醇提取物和水提起物可减少醋酸致小鼠扭体次数,延长小鼠舔足时间,减轻二甲苯致小鼠耳廓肿胀程度,减小角叉莱胶致足跖肿胀程度；乙醇提取物作用强于水提取物。结论：中药仙鹤草乙醇提取物具有明显的镇痛抗炎作用。
Objective：To investigate the anti-inflammatory and analgesic effects of extract of Herba agrimoniae. Methods：The anti- inflammatory and analgesic effects of alcohol extract and water extract from Herba agrimoniae were observed by means of acetic acid inducing mouse writhing model, hot plate method , dimethylbenzene inducing ear edema model and carrageenan inducing rat voix pedis swell model. Results： It was found that alcohol extract and water extract from Herba agrimoniae markedly reducing the writhing frequency induced by acetic acid, significantly increasing the pain threshold in mice induced by hot plate , evidently suppressing the mouse＇ s ear edema induced by dimethylbenzene and significantly mitigating the rat voix pedis swell inducing by canageenan. The action of alcohol extract was better than which of water extract. Conclusion：The alcohol extract fi＇om Herba agrimoniae has notable effects on anti-inflammation and analgesia.
出处
《药学实践杂志》
CAS
2006年第6期339-341,356,共4页
Journal of Pharmaceutical Practice
关键词
仙鹤草
提取物
镇痛
抗炎
Herba agrimoniae
extract
analgesia
anti-inflammation
作者简介
龚纯贵（1973-），男，主管药师．E-mail：aquea@126．com.
